Synthesis, analgesic and antimicrobial activity of substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxo-4-phenylbut-2-enoates
Yu O Sharavyeva
1
,
A I Siutkina
1, 2
,
S V Chashchina
1, 2
,
V V Novikova
2
,
R R Makhmudov
1, 3
,
S A Shipilovskikh
1, 4
3
Federal Scientific Center of Medical and Preventive Health Risks Management Technologies, Perm, Russian Federation
|
Publication type: Journal Article
Publication date: 2022-03-01
scimago Q3
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Abstract
New substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxo-4-phenylbut-2-enoates were obtained by the reaction of 2-((2-oxo-5-phenylfuran-3(2H)-ylidene)-amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile with alcohols. The structures of the compounds obtained were confirmed by 1H and 13C NMR spectroscopy and elemental analysis. A number of new compounds were found to have a pronounced analgesic activity, as well as a weak antimicrobial effect or its absence.
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31
Total citations:
31
Citations from 2024:
11
(35.48%)
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Sharavyeva Yu. O. et al. Synthesis, analgesic and antimicrobial activity of substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxo-4-phenylbut-2-enoates // Russian Chemical Bulletin. 2022. Vol. 71. No. 3. pp. 538-542.
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Sharavyeva Yu. O., Siutkina A. I., Chashchina S. V., Novikova V. V., Makhmudov R. R., Shipilovskikh S. A. Synthesis, analgesic and antimicrobial activity of substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxo-4-phenylbut-2-enoates // Russian Chemical Bulletin. 2022. Vol. 71. No. 3. pp. 538-542.
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TY - JOUR
DO - 10.1007/s11172-022-3445-y
UR - https://doi.org/10.1007/s11172-022-3445-y
TI - Synthesis, analgesic and antimicrobial activity of substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxo-4-phenylbut-2-enoates
T2 - Russian Chemical Bulletin
AU - Sharavyeva, Yu O
AU - Siutkina, A I
AU - Chashchina, S V
AU - Novikova, V V
AU - Makhmudov, R R
AU - Shipilovskikh, S A
PY - 2022
DA - 2022/03/01
PB - Springer Nature
SP - 538-542
IS - 3
VL - 71
SN - 1066-5285
SN - 1573-9171
ER -
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BibTex (up to 50 authors)
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@article{2022_Sharavyeva,
author = {Yu O Sharavyeva and A I Siutkina and S V Chashchina and V V Novikova and R R Makhmudov and S A Shipilovskikh},
title = {Synthesis, analgesic and antimicrobial activity of substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxo-4-phenylbut-2-enoates},
journal = {Russian Chemical Bulletin},
year = {2022},
volume = {71},
publisher = {Springer Nature},
month = {mar},
url = {https://doi.org/10.1007/s11172-022-3445-y},
number = {3},
pages = {538--542},
doi = {10.1007/s11172-022-3445-y}
}
Cite this
MLA
Copy
Sharavyeva, Yu. O., et al. “Synthesis, analgesic and antimicrobial activity of substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxo-4-phenylbut-2-enoates.” Russian Chemical Bulletin, vol. 71, no. 3, Mar. 2022, pp. 538-542. https://doi.org/10.1007/s11172-022-3445-y.