A new tetrazole-containing 2-amino-4,6-di(aziridin-1-yl)-1,3,5-triazine derivative: synthesis, interaction with DNA, and antitumor activity
O V Mikolaichuk
1, 2, 3
,
V V Sharoyko
1, 2
,
E. A. Popova
1, 3
,
A V Protas
1, 3
,
A V Fonin
4
,
Yu A Anufrikov
1
,
A M Malkova
1, 2
,
N T Shmaneva
5
,
V A Ostrovskii
5
,
O E Molchanov
3
,
D N Maistrenko
3
,
K N Semenov
1, 2
Publication type: Journal Article
Publication date: 2022-05-21
scimago Q3
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Abstract
({5-[4,6-Di(aziridin-1-yl)-1,3,5-triazin-2-yl]amino}-2,2-dimethyl-1,3-dioxan-5-yl)-methyl 2-(5-phenyl-2H-tetrazol-2-yl)acetate was synthesized and characterized. The interaction of the obtained tetrazole-containing 2-amino-4,6-di(aziridin-1-yl)-1,3,5-triazine derivative with DNA was studied by UV spectrophotometry, circular dichroism spectroscopy, and isothermal calorimetry. The values of binding constants (9.65·108 L mol−1, UV spectrophotometry; 4.08·108 L mol−1, isothermal calorimetry) of the 1,3,5-triazine derivative to DNA attests to efficient binding and formation of stable associates with the biopolymer. The addition of the tetrazole-containing 1,3,5-triazine derivative to a DNA solution has virtually no effect on the DNA melting point. The tetrazole-containing 1,3,5-triazine derivative exhibits a cytostatic effect on SK-HEP-1 human hepatic adenocarcinoma cells (half-maximal inhibitory concentration IC50 22.2 mmol L−1) and T98G human glioblastoma cells (IC50 44.9 mmol L−1).
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Total citations:
11
Citations from 2024:
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(45%)
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Mikolaichuk O. V. et al. A new tetrazole-containing 2-amino-4,6-di(aziridin-1-yl)-1,3,5-triazine derivative: synthesis, interaction with DNA, and antitumor activity // Russian Chemical Bulletin. 2022. Vol. 71. No. 5. pp. 1050-1056.
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Mikolaichuk O. V., Sharoyko V. V., Popova E. A., Protas A. V., Fonin A. V., Anufrikov Yu. A., Malkova A. M., Shmaneva N. T., Ostrovskii V. A., Molchanov O. E., Maistrenko D. N., Semenov K. N. A new tetrazole-containing 2-amino-4,6-di(aziridin-1-yl)-1,3,5-triazine derivative: synthesis, interaction with DNA, and antitumor activity // Russian Chemical Bulletin. 2022. Vol. 71. No. 5. pp. 1050-1056.
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TY - JOUR
DO - 10.1007/s11172-022-3507-1
UR - https://doi.org/10.1007/s11172-022-3507-1
TI - A new tetrazole-containing 2-amino-4,6-di(aziridin-1-yl)-1,3,5-triazine derivative: synthesis, interaction with DNA, and antitumor activity
T2 - Russian Chemical Bulletin
AU - Mikolaichuk, O V
AU - Sharoyko, V V
AU - Popova, E. A.
AU - Protas, A V
AU - Fonin, A V
AU - Anufrikov, Yu A
AU - Malkova, A M
AU - Shmaneva, N T
AU - Ostrovskii, V A
AU - Molchanov, O E
AU - Maistrenko, D N
AU - Semenov, K N
PY - 2022
DA - 2022/05/21
PB - Springer Nature
SP - 1050-1056
IS - 5
VL - 71
SN - 1066-5285
SN - 1573-9171
ER -
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@article{2022_Mikolaichuk,
author = {O V Mikolaichuk and V V Sharoyko and E. A. Popova and A V Protas and A V Fonin and Yu A Anufrikov and A M Malkova and N T Shmaneva and V A Ostrovskii and O E Molchanov and D N Maistrenko and K N Semenov},
title = {A new tetrazole-containing 2-amino-4,6-di(aziridin-1-yl)-1,3,5-triazine derivative: synthesis, interaction with DNA, and antitumor activity},
journal = {Russian Chemical Bulletin},
year = {2022},
volume = {71},
publisher = {Springer Nature},
month = {may},
url = {https://doi.org/10.1007/s11172-022-3507-1},
number = {5},
pages = {1050--1056},
doi = {10.1007/s11172-022-3507-1}
}
Cite this
MLA
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Mikolaichuk, O. V., et al. “A new tetrazole-containing 2-amino-4,6-di(aziridin-1-yl)-1,3,5-triazine derivative: synthesis, interaction with DNA, and antitumor activity.” Russian Chemical Bulletin, vol. 71, no. 5, May. 2022, pp. 1050-1056. https://doi.org/10.1007/s11172-022-3507-1.
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