Antioxidant activity of 2H-chromen-2-one derivatives
M A Polovinkina
1
,
V. P. Osipova
1
,
A D Osipova
2
,
I V Kanevskaya
3
,
A L Ivanova
3
,
N V Pchelintseva
3
,
N T Berberova
2
Publication type: Journal Article
Publication date: 2022-12-01
scimago Q3
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Abstract
Moderate antiradical activity of 2H-chromen-2-one derivatives was established in a set of assays. The highest activity towards the superoxide radical anion (O 2 •– ) generated in the model of enzymatic reduction of nitro blue tetrazolium was found for 4-[(1,2,3,4-tetra-hydro-1-oxonaphthalen-2-yl)(piperidin-1-yl)methyl]benzoic acid. In the non-enzymatic oxidation of epinephrine in an alkaline medium, like in other model systems, the highest activity was found for 4-(6-oxo-8,9-dihydro-6H,7H-benzo[h]-chromene[4,3-b]chromen-7-yl)benzoic acid. The absence of pronounced Fe2+-chelating activity and low reducing activity were revealed for 2H-chromen-2-one derivatives. In the model of long-lasting lipid peroxidation of tilapia liver, prolonged antioxidant effect was established for all of the test derivatives.
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Polovinkina M. A. et al. Antioxidant activity of 2H-chromen-2-one derivatives // Russian Chemical Bulletin. 2022. Vol. 71. No. 12. pp. 2645-2653.
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Polovinkina M. A., Osipova V. P., Osipova A. D., Kanevskaya I. V., Ivanova A. L., Pchelintseva N. V., Berberova N. T. Antioxidant activity of 2H-chromen-2-one derivatives // Russian Chemical Bulletin. 2022. Vol. 71. No. 12. pp. 2645-2653.
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TY - JOUR
DO - 10.1007/s11172-022-3694-9
UR - https://doi.org/10.1007/s11172-022-3694-9
TI - Antioxidant activity of 2H-chromen-2-one derivatives
T2 - Russian Chemical Bulletin
AU - Polovinkina, M A
AU - Osipova, V. P.
AU - Osipova, A D
AU - Kanevskaya, I V
AU - Ivanova, A L
AU - Pchelintseva, N V
AU - Berberova, N T
PY - 2022
DA - 2022/12/01
PB - Springer Nature
SP - 2645-2653
IS - 12
VL - 71
SN - 1066-5285
SN - 1573-9171
ER -
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@article{2022_Polovinkina,
author = {M A Polovinkina and V. P. Osipova and A D Osipova and I V Kanevskaya and A L Ivanova and N V Pchelintseva and N T Berberova},
title = {Antioxidant activity of 2H-chromen-2-one derivatives},
journal = {Russian Chemical Bulletin},
year = {2022},
volume = {71},
publisher = {Springer Nature},
month = {dec},
url = {https://doi.org/10.1007/s11172-022-3694-9},
number = {12},
pages = {2645--2653},
doi = {10.1007/s11172-022-3694-9}
}
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MLA
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Polovinkina, M. A., et al. “Antioxidant activity of 2H-chromen-2-one derivatives.” Russian Chemical Bulletin, vol. 71, no. 12, Dec. 2022, pp. 2645-2653. https://doi.org/10.1007/s11172-022-3694-9.