Crystal structures and antimicrobial and antioxidant activities of phosphonium compounds containing 3,5-di-tert-butyl-4-hydroxybenzyl fragment

The antimicrobial and antioxidant properties of a series of organophosphorous compounds containing the 3,5-di-tert-butyl-4-hydroxybenzyl fragment were studied. As revealed in biological activity assays, the majority of the compounds simultaneously possesses high antibacterial and fungicidal activities against pathogenic and arbitrarily pathogenic human and animal microflora. The influence of the substituents at the phosphonate phosphorus atom and the number of fragments of sterically hindered phenol on the antioxidant capacity of the studied compounds was found. In the case of methoxyl substituents at the phosphonate phosphorus atom, the antioxidant activity decreases sharply compared to the initial antioxidant, ionol (2,6-di-tert-butylphenol), whereas the phenoxyl substituents at the phosphorus atom sharply increase the antioxidant activity of the studied salts.