N-(2-Carboxyphenyl)oxalamides in the synthesis of the quinazoline central nervous system depressant methaqualone and fused biheterocyclic systems
Publication type: Journal Article
Publication date: 2024-07-01
scimago Q3
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
Abstract
A synthesis of the quinazolin-4-one pharmacological agent methaqualone from N-(2-carboxyphenyl)oxalamide was developed. A new method for the reductive cyclization of 3-(2-nitrophenyl)quinazolin-4-ones to benzimidazo[2,1-b]quinazolin-12(6H)-ones, the 6-deoxo-6-aza analogs of natural alkaloid tryptanthrine, was suggested and new derivatives of poorly available quinoxalinoquinazolinone fused system were synthesized.
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Mamedova V. L. et al. N-(2-Carboxyphenyl)oxalamides in the synthesis of the quinazoline central nervous system depressant methaqualone and fused biheterocyclic systems // Russian Chemical Bulletin. 2024. Vol. 73. No. 7. pp. 1996-2003.
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Mamedova V. L., Kushatov T. A., TIKHOMIROVA N. A., Sinyashin O. G., Mamedov V. A. N-(2-Carboxyphenyl)oxalamides in the synthesis of the quinazoline central nervous system depressant methaqualone and fused biheterocyclic systems // Russian Chemical Bulletin. 2024. Vol. 73. No. 7. pp. 1996-2003.
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TY - JOUR
DO - 10.1007/s11172-024-4319-2
UR - https://link.springer.com/10.1007/s11172-024-4319-2
TI - N-(2-Carboxyphenyl)oxalamides in the synthesis of the quinazoline central nervous system depressant methaqualone and fused biheterocyclic systems
T2 - Russian Chemical Bulletin
AU - Mamedova, V L
AU - Kushatov, T. A.
AU - TIKHOMIROVA, N. A.
AU - Sinyashin, O G
AU - Mamedov, V A
PY - 2024
DA - 2024/07/01
PB - Springer Nature
SP - 1996-2003
IS - 7
VL - 73
SN - 1066-5285
SN - 1573-9171
ER -
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@article{2024_Mamedova,
author = {V L Mamedova and T. A. Kushatov and N. A. TIKHOMIROVA and O G Sinyashin and V A Mamedov},
title = {N-(2-Carboxyphenyl)oxalamides in the synthesis of the quinazoline central nervous system depressant methaqualone and fused biheterocyclic systems},
journal = {Russian Chemical Bulletin},
year = {2024},
volume = {73},
publisher = {Springer Nature},
month = {jul},
url = {https://link.springer.com/10.1007/s11172-024-4319-2},
number = {7},
pages = {1996--2003},
doi = {10.1007/s11172-024-4319-2}
}
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Mamedova, V. L., et al. “N-(2-Carboxyphenyl)oxalamides in the synthesis of the quinazoline central nervous system depressant methaqualone and fused biheterocyclic systems.” Russian Chemical Bulletin, vol. 73, no. 7, Jul. 2024, pp. 1996-2003. https://link.springer.com/10.1007/s11172-024-4319-2.
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