Histopathological and genotoxic effects of chlorpyrifos in rats
Ezzi Lobna
1
,
Imen Belhadj Salah
1
,
Zohra Haouas
1
,
Amina Sakly
1
,
Grissa Intissar
1
,
Chakroun Sana
1
,
Emna Kerkeni
1
,
Mohsen Hassine
2
,
Meriem Mehdi
1
,
Hassen Ben Cheikh
1
Publication type: Journal Article
Publication date: 2015-11-06
scimago Q1
SJR: 1.004
CiteScore: 10.6
Impact factor: —
ISSN: 09441344, 16147499
PubMed ID:
26545888
General Medicine
Environmental Chemistry
Health, Toxicology and Mutagenesis
Pollution
Abstract
This study aims to investigate the effects of chlorpyrifos’s sub-acute exposure on male rats. Two groups with six animals each were orally treated, respectively, with 3.1 mg/kg b w and 6.2 mg/kg b w of chlorpyrifos during 4 weeks. The genotoxic effect of chlopyrifos was investigated using the comet assay and the micronucleus test. Some hematological and liver’s histopathological changes were also evaluated. Results revealed that chlorpyrifos induced histopathological alterations in liver parenchyma. The lymphoid infiltration observed in liver sections and the increase in white blood cells parameter are signs of inflammation. A significant increase in the platelet’ count and in polychromatic erythrocytes/normochromatic erythrocytes (PCE/NCE) ratio was observed in chlorpyrifos-treated groups which could be due to the stimulatory effect of chlorpyrifos on cell formation in the bone marrow at lower doses. In addition, the increase of bone marrow micronucleus percentage and the comet tail length revealed a genotoxic potential of chlorpyrifos in vivo.
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Total citations:
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Citations from 2024:
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(9.76%)
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GOST
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Lobna E. et al. Histopathological and genotoxic effects of chlorpyrifos in rats // Environmental Science and Pollution Research. 2015. Vol. 23. No. 5. pp. 4859-4867.
GOST all authors (up to 50)
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Lobna E., Belhadj Salah I., Haouas Z., Sakly A., Intissar G., Sana C., Kerkeni E., Hassine M., Mehdi M., Ben Cheikh H. Histopathological and genotoxic effects of chlorpyrifos in rats // Environmental Science and Pollution Research. 2015. Vol. 23. No. 5. pp. 4859-4867.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1007/s11356-015-5722-x
UR - https://doi.org/10.1007/s11356-015-5722-x
TI - Histopathological and genotoxic effects of chlorpyrifos in rats
T2 - Environmental Science and Pollution Research
AU - Lobna, Ezzi
AU - Belhadj Salah, Imen
AU - Haouas, Zohra
AU - Sakly, Amina
AU - Intissar, Grissa
AU - Sana, Chakroun
AU - Kerkeni, Emna
AU - Hassine, Mohsen
AU - Mehdi, Meriem
AU - Ben Cheikh, Hassen
PY - 2015
DA - 2015/11/06
PB - Springer Nature
SP - 4859-4867
IS - 5
VL - 23
PMID - 26545888
SN - 0944-1344
SN - 1614-7499
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2015_Lobna,
author = {Ezzi Lobna and Imen Belhadj Salah and Zohra Haouas and Amina Sakly and Grissa Intissar and Chakroun Sana and Emna Kerkeni and Mohsen Hassine and Meriem Mehdi and Hassen Ben Cheikh},
title = {Histopathological and genotoxic effects of chlorpyrifos in rats},
journal = {Environmental Science and Pollution Research},
year = {2015},
volume = {23},
publisher = {Springer Nature},
month = {nov},
url = {https://doi.org/10.1007/s11356-015-5722-x},
number = {5},
pages = {4859--4867},
doi = {10.1007/s11356-015-5722-x}
}
Cite this
MLA
Copy
Lobna, Ezzi, et al. “Histopathological and genotoxic effects of chlorpyrifos in rats.” Environmental Science and Pollution Research, vol. 23, no. 5, Nov. 2015, pp. 4859-4867. https://doi.org/10.1007/s11356-015-5722-x.