Mitochondrial-derived peptides in aging and age-related diseases
Publication type: Journal Article
Publication date: 2020-09-10
scimago Q1
wos Q1
SJR: 1.564
CiteScore: 8.6
Impact factor: 5.4
ISSN: 25092715, 25092723
PubMed ID:
32910336
Geriatrics and Gerontology
Aging
Abstract
A decline in mitochondrial quality and activity has been associated with normal aging and correlated with the development of a wide range of age-related diseases. Here, we review the evidence that a decline in the levels of mitochondrial-derived peptides contributes to aging and age-related diseases. In particular, we discuss how mitochondrial-derived peptides, humanin and MOTS-c, contribute to specific aspects of the aging process, including cellular senescence, chronic inflammation, and cognitive decline. Genetic variations in the coding region of humanin and MOTS-c that are associated with age-related diseases are also reviewed, with particular emphasis placed on how mitochondrial variants might, in turn, regulate MDP expression and age-related phenotypes. Taken together, these observations suggest that mitochondrial-derived peptides influence or regulate a number of key aspects of aging and that strategies directed at increasing mitochondrial-derived peptide levels might have broad beneficial effects.
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Metrics
58
Total citations:
58
Citations from 2024:
28
(48.27%)
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GOST
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Kim S. J. et al. Mitochondrial-derived peptides in aging and age-related diseases // GeroScience. 2020. Vol. 43. No. 3. pp. 1113-1121.
GOST all authors (up to 50)
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Kim S. J., Miller B., Kumagai H., Silverstein A. R., Flores M., Yen K. Mitochondrial-derived peptides in aging and age-related diseases // GeroScience. 2020. Vol. 43. No. 3. pp. 1113-1121.
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RIS
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TY - JOUR
DO - 10.1007/s11357-020-00262-5
UR - https://doi.org/10.1007/s11357-020-00262-5
TI - Mitochondrial-derived peptides in aging and age-related diseases
T2 - GeroScience
AU - Kim, Su Jeong
AU - Miller, Brendan
AU - Kumagai, Hiroshi
AU - Silverstein, Ana R
AU - Flores, Melanie
AU - Yen, Kelvin
PY - 2020
DA - 2020/09/10
PB - Springer Nature
SP - 1113-1121
IS - 3
VL - 43
PMID - 32910336
SN - 2509-2715
SN - 2509-2723
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Kim,
author = {Su Jeong Kim and Brendan Miller and Hiroshi Kumagai and Ana R Silverstein and Melanie Flores and Kelvin Yen},
title = {Mitochondrial-derived peptides in aging and age-related diseases},
journal = {GeroScience},
year = {2020},
volume = {43},
publisher = {Springer Nature},
month = {sep},
url = {https://doi.org/10.1007/s11357-020-00262-5},
number = {3},
pages = {1113--1121},
doi = {10.1007/s11357-020-00262-5}
}
Cite this
MLA
Copy
Kim, Su Jeong, et al. “Mitochondrial-derived peptides in aging and age-related diseases.” GeroScience, vol. 43, no. 3, Sep. 2020, pp. 1113-1121. https://doi.org/10.1007/s11357-020-00262-5.