Molecular Neurobiology

, volume 59 , issue 3 , pages 1925-1937

N6-methyladenosine and Neurological Diseases

Nan Zhang ¹

Chunhong Ding ¹

Yuxin Zuo ¹

Peng Yu ¹

Lielian Zuo ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

Department of Physiology, Institute of Neuroscience Research, Hengyang Key Laboratory of Neurodegeneration and Cognitive Impairment, Hengyang Medical College, University of South China, Hengyang, China |

Publication type: Journal Article

Publication date: 2022-01-15

Springer Nature

Molecular Neurobiology

scimago Q1

wos Q1

SJR: 1.397

CiteScore: 8.4

Impact factor: 4.3

ISSN: 08937648, 15591182

DOI: 10.1007/s12035-022-02739-0

Copy DOI

PubMed ID: 35032318

Neurology

Cellular and Molecular Neuroscience

Neuroscience (miscellaneous)

Abstract

N6-methyladenosine (m6A) is a dynamic reversible methylation modification of the adenosine N6 position and is the most common chemical epigenetic modification among mRNA post-transcriptional modifications, including methylation, demethylation, and recognition. Post-transcriptional modification involves multiple protein molecules, including METTL3, METTL14, WTAP, KIAA1429, ALKBH5, YTHDF1/2/3, and YTHDC1/2. m6A-related proteins are expressed in almost all cells. However, the abnormal expression of m6A-related proteins may occur in the nervous system, thereby affecting neuritogenesis, brain volume, learning and memory, memory formation and consolidation, etc., and is implicated in the development of diseases, such as Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, depression, epilepsy, and brain tumors. This review focuses on the functions of m6A in the development of central nervous system diseases, thus contributing to a deeper understanding of disease pathogenesis and providing potential clinical therapeutic targets for neurological diseases.

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Zhao Yujia

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GOST |

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GOST Copy

Zhang N. et al. N6-methyladenosine and Neurological Diseases // Molecular Neurobiology. 2022. Vol. 59. No. 3. pp. 1925-1937.

GOST all authors (up to 50) Copy

Zhang N., Ding C., Zuo Y., Yu P., Zuo L. N6-methyladenosine and Neurological Diseases // Molecular Neurobiology. 2022. Vol. 59. No. 3. pp. 1925-1937.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1007/s12035-022-02739-0

UR - https://doi.org/10.1007/s12035-022-02739-0

TI - N6-methyladenosine and Neurological Diseases

T2 - Molecular Neurobiology

AU - Zhang, Nan

AU - Ding, Chunhong

AU - Zuo, Yuxin

AU - Yu, Peng

AU - Zuo, Lielian

PY - 2022

DA - 2022/01/15

PB - Springer Nature

SP - 1925-1937

IS - 3

VL - 59

PMID - 35032318

SN - 0893-7648

SN - 1559-1182

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2022_Zhang,

author = {Nan Zhang and Chunhong Ding and Yuxin Zuo and Peng Yu and Lielian Zuo},

title = {N6-methyladenosine and Neurological Diseases},

journal = {Molecular Neurobiology},

year = {2022},

volume = {59},

publisher = {Springer Nature},

month = {jan},

url = {https://doi.org/10.1007/s12035-022-02739-0},

number = {3},

pages = {1925--1937},

doi = {10.1007/s12035-022-02739-0}

}

MLA

Cite this

MLA Copy

Zhang, Nan, et al. “N6-methyladenosine and Neurological Diseases.” Molecular Neurobiology, vol. 59, no. 3, Jan. 2022, pp. 1925-1937. https://doi.org/10.1007/s12035-022-02739-0.

Publisher

Springer Nature

Journal

Molecular Neurobiology

scimago Q1

wos Q1

SJR

1.397

CiteScore

8.4

Impact factor

4.3

ISSN

08937648 (Print)

15591182 (Electronic)