Open Access
Open access
Journal of Cell Communication and Signaling, volume 14, issue 3, pages 293-301

Gasdermin family: a promising therapeutic target for cancers and inflammation-driven diseases

Publication type: Journal Article
Publication date: 2020-03-31
scimago Q1
SJR: 1.113
CiteScore: 6.4
Impact factor: 3.6
ISSN: 18739601, 1873961X
Biochemistry
Molecular Biology
Cell Biology
Abstract
This review focuses on current advances in researches of gasdermin family. The distinctive expression patterns and biological roles of members in this family were discussed. Most of them exhibit pore-forming activity on cell membranes and are executors for programmed cell death with cytokines release, and play roles in cancers and inflammation-driven diseases. Therefore, they can be used as potential therapeutic targets to treat related diseases.
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