Human Cell

, volume 36 , issue 1

Mitochondria: how eminent in ageing and neurodegenerative disorders?

Chia Bamshad ¹

Nima Najafi-Ghalehlou ²

Zahra Pourmohammadi Bejarpasi ³

Kazuo Tomita ⁴

Yoshikazu Kuwahara ⁵

Tomoaki Sato ⁴

Alireza Feizkhah ³

Amaneh Mohammadi Roushnadeh ³

Mehryar Habibi Roudkenar ³

Hide authors affiliations Show authors affiliations: 5 affiliations

Department of Medical Biotechnology, Faculty of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran |

Department of Medical Laboratory Sciences, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran |

Burn and Regenerative Medicine Research Center, School of Medicine, Velayat Hospital, Guilan University of Medical Sciences, Rasht, Iran |

⁴

Department of Applied Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan |

⁵

Division of Radiation Biology and Medicine, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan |

Publication type: Journal Article

Publication date: 2022-11-29

Springer Nature

Human Cell

scimago Q2

wos Q3

SJR: 0.890

CiteScore: 6.6

Impact factor: 3.1

ISSN: 09147470, 17490774

DOI: 10.1007/s13577-022-00833-y

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PubMed ID: 36445534

Cancer Research

Cell Biology

Abstract

Numerous factors are implicated in the onset and progression of ageing and neurodegenerative disorders, with defects in cell energy supply and free radicals regulation designated as being the main functions of mitochondria and highly accentuated in plentiful studies. Hence, analysing the role of mitochondria as one of the main factors implicated in these disorders could undoubtedly come in handy with respect to disease prevention and treatment. In this review, first, we will explore how mitochondria account for neurodegenerative disorders and ageing and later will draw the various pathways contributing to mitochondrial dysfunction in their distinct way. Also, we will discuss the deviation-countering mechanisms, particularly mitophagy, a subset of autophagy known as a much larger cellular defence mechanism and regulatory system, along with its potential therapeutic effects. Last but not least, we will be highlighting the mitochondrial transfer experiments with animal models of neurodegenerative disorders.

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Bamshad C. et al. Mitochondria: how eminent in ageing and neurodegenerative disorders? // Human Cell. 2022. Vol. 36. No. 1.

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Bamshad C., Najafi-Ghalehlou N., Pourmohammadi Bejarpasi Z., Tomita K., Kuwahara Y., Sato T., Feizkhah A., Roushnadeh A. M., Habibi Roudkenar M. Mitochondria: how eminent in ageing and neurodegenerative disorders? // Human Cell. 2022. Vol. 36. No. 1.

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