Redoxification (of the Organism) Through Diet and Supplementation with a Focus on Natural Polymeric Redox Modulators

Oxidative stress, characterized by an imbalance between reactive oxygen species production and the body’s antioxidant defence mechanisms, has been implicated in the pathogenesis of numerous diseases. This review highlights the possible mechanisms of influence of natural polymeric redox modulators in human organism as well as an importance of supplementation with these metabolites as a promising tool to counteract oxidative stress. The first part provides an overview of oxidative stress and its role in the development of various pathological conditions. The second part of the manuscript focuses on natural redox modulators, highlighting their unique properties and diverse sources, including plant-based bioactive polymers. The third section explores the potential therapeutic applications of natural polymeric redox modulators in oxidative stress–related diseases. Furthermore, the potential synergistic effects of natural redox modulators with conventional therapies have also been discussed, suggesting their value in combination treatments. The review article also addresses the challenges and opportunities in the field of natural polymeric redox modulator supplementation, including enhanced bioavailability, stability and safety considerations. Future directions and emerging research areas, such as personalized supplementation, are also explored, underscoring the need for further investigation and optimization of these compounds. Supplementation with natural polymeric redox modulators represents a promising strategy to combat oxidative stress–related diseases. Their unique properties, diverse sources and potential synergistic effects open avenues for novel therapeutic interventions and improved patient outcomes. According to the current-stage investigation, further research and clinical trials are warranted to harness the full potential of these natural compounds.