Macrolactins: biological activity and biosynthesis
2
Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, China
|
Publication type: Journal Article
Publication date: 2020-10-14
scimago Q1
wos Q1
SJR: 1.139
CiteScore: 9.4
Impact factor: 5.3
ISSN: 26621746, 20966490
PubMed ID:
37073393
Biotechnology
Ecology, Evolution, Behavior and Systematics
Aquatic Science
Oceanography
Abstract
Marine microorganisms have proven to be a rich source of natural products with unique structures and novel activities, due to their special living conditions. Macrolactins (MLNs), mostly produced by marine-derived microorganisms, are a group of 24-membered lactone natural products, which exhibit potent antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, anti-angiogenic and other activities. Their extensive biological activities make them potential compounds for drug development. MLNs are biosynthesized via a type I polyketide synthase (PKS) pathway with different tailoring steps, such as epoxidation, glycosylation and acylation. These modification steps provide opportunities to diversify their structures by combinatorial biosynthesis strategies. This review mainly focuses on the newly discovered MLNs in the past five years, including their biological activities and relevant biosynthetic studies.
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Metrics
21
Total citations:
21
Citations from 2025:
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(61.9%)
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BibTex |
MLA
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GOST
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Wu T. et al. Macrolactins: biological activity and biosynthesis // Marine Life Science & Technology. 2020. Vol. 3. No. 1. pp. 62-68.
GOST all authors (up to 50)
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Wu T., Xiao F., Li W. Macrolactins: biological activity and biosynthesis // Marine Life Science & Technology. 2020. Vol. 3. No. 1. pp. 62-68.
Cite this
RIS
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TY - JOUR
DO - 10.1007/s42995-020-00068-6
UR - https://doi.org/10.1007/s42995-020-00068-6
TI - Macrolactins: biological activity and biosynthesis
T2 - Marine Life Science & Technology
AU - Wu, Ting
AU - Xiao, Fei
AU - Li, Wenli
PY - 2020
DA - 2020/10/14
PB - Springer Nature
SP - 62-68
IS - 1
VL - 3
PMID - 37073393
SN - 2662-1746
SN - 2096-6490
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Wu,
author = {Ting Wu and Fei Xiao and Wenli Li},
title = {Macrolactins: biological activity and biosynthesis},
journal = {Marine Life Science & Technology},
year = {2020},
volume = {3},
publisher = {Springer Nature},
month = {oct},
url = {https://doi.org/10.1007/s42995-020-00068-6},
number = {1},
pages = {62--68},
doi = {10.1007/s42995-020-00068-6}
}
Cite this
MLA
Copy
Wu, Ting, et al. “Macrolactins: biological activity and biosynthesis.” Marine Life Science & Technology, vol. 3, no. 1, Oct. 2020, pp. 62-68. https://doi.org/10.1007/s42995-020-00068-6.