Copalic Acid: Occurrence, Chemistry, and Biological Activities
Publication type: Journal Article
Publication date: 2021-08-10
scimago Q2
wos Q4
SJR: 0.366
CiteScore: 2.9
Impact factor: 1.6
ISSN: 0102695X, 1981528X
General Pharmacology, Toxicology and Pharmaceutics
Abstract
(–)-Copalic acid is a naturally occurring labdane‐type diterpene acid usually isolated from oleoresins of Copaifera trees, being considered the biomarker for the genus. This compound has shown many remarkable biological and pharmacological activities, including anti-inflammatory, antimicrobial, antiparasitic, cytotoxic, chemopreventive, antimutagenic, and antigenotoxic activities, which have attracted interest in its use as a prototype for the development of new drugs. This review was organized to describe the extraction, isolation, and analytical methods for quantification and structural elucidation, biological and pharmacological activities, pharmacokinetic and toxicological studies, and several semisynthetic derivatives of copalic acid. Some remaining gaps related to the reviewed activities are also mentioned, while the perspectives for future research with copalic acid are proposed.
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Medeiros V. G. et al. Copalic Acid: Occurrence, Chemistry, and Biological Activities // Revista Brasileira de Farmacognosia. 2021. Vol. 31. No. 4. pp. 375-386.
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Medeiros V. G., Durán F. J., Lang K. L. Copalic Acid: Occurrence, Chemistry, and Biological Activities // Revista Brasileira de Farmacognosia. 2021. Vol. 31. No. 4. pp. 375-386.
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TY - JOUR
DO - 10.1007/s43450-021-00173-2
UR - https://doi.org/10.1007/s43450-021-00173-2
TI - Copalic Acid: Occurrence, Chemistry, and Biological Activities
T2 - Revista Brasileira de Farmacognosia
AU - Medeiros, Vanessa Gonçalves
AU - Durán, Fernando Javier
AU - Lang, Karen Luise
PY - 2021
DA - 2021/08/10
PB - Springer Nature
SP - 375-386
IS - 4
VL - 31
SN - 0102-695X
SN - 1981-528X
ER -
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BibTex (up to 50 authors)
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@article{2021_Medeiros,
author = {Vanessa Gonçalves Medeiros and Fernando Javier Durán and Karen Luise Lang},
title = {Copalic Acid: Occurrence, Chemistry, and Biological Activities},
journal = {Revista Brasileira de Farmacognosia},
year = {2021},
volume = {31},
publisher = {Springer Nature},
month = {aug},
url = {https://doi.org/10.1007/s43450-021-00173-2},
number = {4},
pages = {375--386},
doi = {10.1007/s43450-021-00173-2}
}
Cite this
MLA
Copy
Medeiros, Vanessa Gonçalves, et al. “Copalic Acid: Occurrence, Chemistry, and Biological Activities.” Revista Brasileira de Farmacognosia, vol. 31, no. 4, Aug. 2021, pp. 375-386. https://doi.org/10.1007/s43450-021-00173-2.