The Anti-angiogenic and Anti-microbial Effect of Diosmin: Potential Receptor Interactions via Molecular Docking
Ece Şimşek
1, 2, 3
,
Orhan Koçak
3, 4
,
Kübra Yıldırım
1, 3
,
Aykut Kuruoğlu
5
,
Nazlı Deniz Taşkın
6
,
Serhat Bozkurt
3
,
Nilüfer İmir
7
,
Cemilenur Ataş
2, 3
,
Esra Tanyel Akçit
2, 3
,
Mustafa Çoban
8
,
Ahmet Yılmaz Çoban
1, 2, 3
5
İzmir Biomedicine and Genome Center, İzmir, Turkey
|
Publication type: Journal Article
Publication date: 2023-02-25
scimago Q2
wos Q4
SJR: 0.366
CiteScore: 2.9
Impact factor: 1.6
ISSN: 0102695X, 1981528X
General Pharmacology, Toxicology and Pharmaceutics
Abstract
This study examined the antiangiogenic capacity of diosmin in vitro and their interactions with certain important receptors related to cancer and infectious diseases via molecular docking. Diosmin, a naturally occurring flavone glycoside, largely found in citrus fruits, exhibits potentially antiangiogenic properties especially interacting with both VEGF and VEGFR. Treatment with certain doses of diosmin caused a reduction with a ratio of 22–68% on VEGF levels as compared to non-treated control groups. Western blotting and real-time PCR results demonstrated that protein expression of VEGF was downregulated in a dose- and time-dependent manner. On the other hand, we aimed to check the possible interaction of diosmin with VEGF, VEGFR, HER, PR, ER, and Omp-a, receptor proteins. According to our molecular docking results, diosmin effectively binds these receptors and probably this could be one of the possible reasons for its anti-angiogenic and anti-microbial properties.
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Şimşek E. et al. The Anti-angiogenic and Anti-microbial Effect of Diosmin: Potential Receptor Interactions via Molecular Docking // Revista Brasileira de Farmacognosia. 2023. Vol. 33. No. 2. pp. 422-431.
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Şimşek E., Koçak O., Yıldırım K., Kuruoğlu A., Taşkın N. D., Bozkurt S., İmir N., Ataş C., Akçit E. T., Çoban M., Çoban A. Y. The Anti-angiogenic and Anti-microbial Effect of Diosmin: Potential Receptor Interactions via Molecular Docking // Revista Brasileira de Farmacognosia. 2023. Vol. 33. No. 2. pp. 422-431.
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TY - JOUR
DO - 10.1007/s43450-023-00365-y
UR - https://doi.org/10.1007/s43450-023-00365-y
TI - The Anti-angiogenic and Anti-microbial Effect of Diosmin: Potential Receptor Interactions via Molecular Docking
T2 - Revista Brasileira de Farmacognosia
AU - Şimşek, Ece
AU - Koçak, Orhan
AU - Yıldırım, Kübra
AU - Kuruoğlu, Aykut
AU - Taşkın, Nazlı Deniz
AU - Bozkurt, Serhat
AU - İmir, Nilüfer
AU - Ataş, Cemilenur
AU - Akçit, Esra Tanyel
AU - Çoban, Mustafa
AU - Çoban, Ahmet Yılmaz
PY - 2023
DA - 2023/02/25
PB - Springer Nature
SP - 422-431
IS - 2
VL - 33
SN - 0102-695X
SN - 1981-528X
ER -
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@article{2023_Şimşek,
author = {Ece Şimşek and Orhan Koçak and Kübra Yıldırım and Aykut Kuruoğlu and Nazlı Deniz Taşkın and Serhat Bozkurt and Nilüfer İmir and Cemilenur Ataş and Esra Tanyel Akçit and Mustafa Çoban and Ahmet Yılmaz Çoban},
title = {The Anti-angiogenic and Anti-microbial Effect of Diosmin: Potential Receptor Interactions via Molecular Docking},
journal = {Revista Brasileira de Farmacognosia},
year = {2023},
volume = {33},
publisher = {Springer Nature},
month = {feb},
url = {https://doi.org/10.1007/s43450-023-00365-y},
number = {2},
pages = {422--431},
doi = {10.1007/s43450-023-00365-y}
}
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MLA
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Şimşek, Ece, et al. “The Anti-angiogenic and Anti-microbial Effect of Diosmin: Potential Receptor Interactions via Molecular Docking.” Revista Brasileira de Farmacognosia, vol. 33, no. 2, Feb. 2023, pp. 422-431. https://doi.org/10.1007/s43450-023-00365-y.