Open Access
Methylated polyamines as research tools.
Alex R. Khomutov
1
,
Janne Weisell
2
,
Maxim A. Khomutov
1
,
Nikolay A Grigorenko
3
,
Alina R Simonian
1
,
Merja R. Häkkinen
4
,
Tuomo A. Keinänen
5
,
Mervi T. Hyvönen
5
,
Leena Alhonen
6
,
Jouko Vepsäläinen
2
3
BASF, GVP/SI, Basel, Switzerland
|
Publication type: Book Chapter
Publication date: 2011-02-11
scimago Q4
SJR: 0.354
CiteScore: 2.1
Impact factor: —
ISSN: 10643745, 19406029
PubMed ID:
21318892
Abstract
Earlier unknown racemic β-methylspermidine (β-MeSpd) and γ-methylspermidine (γ-MeSpd) were -synthesized starting from crotononitrile or methacrylonitrile and putrescine. Lithium aluminum hydride reduction of the intermediate di-Boc-nitriles resulted in corresponding di-Boc-amines, which after deprotection gave target β- and γ-MeSpd's. To prepare α-MeSpd, the starting compound, 3-amino-1-butanol, was converted into N-Cbz-3-amino-1-butyl methanesulfonate, which alkylated putrescine to give (after deprotection of amino group) the required α-MeSpd. Novel β- and γ-MeSpd's in combination with earlier α-MeSpd are useful tools for studying enzymology and cell biology of polyamines.
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Total citations:
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Citations from 2025:
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GOST
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Khomutov A. R. et al. Methylated polyamines as research tools. // Methods in Molecular Biology. 2011. Vol. 720. pp. 449-461.
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Khomutov A. R., Weisell J., Khomutov M. A., Grigorenko N. A., Simonian A. R., Häkkinen M. R., Keinänen T. A., Hyvönen M. T., Alhonen L., Kochetkov S. N., Vepsäläinen J. Methylated polyamines as research tools. // Methods in Molecular Biology. 2011. Vol. 720. pp. 449-461.
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RIS
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TY - GENERIC
DO - 10.1007/978-1-61779-034-8_29
UR - https://doi.org/10.1007/978-1-61779-034-8_29
TI - Methylated polyamines as research tools.
T2 - Methods in Molecular Biology
AU - Khomutov, Alex R.
AU - Weisell, Janne
AU - Khomutov, Maxim A.
AU - Grigorenko, Nikolay A
AU - Simonian, Alina R
AU - Häkkinen, Merja R.
AU - Keinänen, Tuomo A.
AU - Hyvönen, Mervi T.
AU - Alhonen, Leena
AU - Kochetkov, Sergey N.
AU - Vepsäläinen, Jouko
PY - 2011
DA - 2011/02/11
PB - Springer Nature
SP - 449-461
VL - 720
PMID - 21318892
SN - 1064-3745
SN - 1940-6029
ER -
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BibTex (up to 50 authors)
Copy
@incollection{2011_Khomutov,
author = {Alex R. Khomutov and Janne Weisell and Maxim A. Khomutov and Nikolay A Grigorenko and Alina R Simonian and Merja R. Häkkinen and Tuomo A. Keinänen and Mervi T. Hyvönen and Leena Alhonen and Sergey N. Kochetkov and Jouko Vepsäläinen},
title = {Methylated polyamines as research tools.},
publisher = {Springer Nature},
year = {2011},
volume = {720},
pages = {449--461},
month = {feb}
}
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