Increased expression of human reduced folate carrier in fetal Down syndrome brain
Publication type: Book Chapter
Publication date: 2003-01-01
SJR: —
CiteScore: —
Impact factor: —
ISSN: 03036995
PubMed ID:
15068242
Abstract
Down syndrome (trisomy of chromosome 21) (DS) is the most common genetic cause of mental retardation. In our study we employed immunoblotting to evaluate protein expression of reduced folate carrier (hRFC), encoded by a gene localised on chromosome 21, in fetal DS brain. We observed increased expression of hRFC-immunoreactive band with an apparent MW of approximately 150kDa, whereas the other bands (MWs ∼60 and 50kDa), were comparable to control. In conclusion, we suggest that aberrant hRFC expression may well have a role in the already observed deterioration of folate metabolism in DS. Moreover, no alterations of expression level of p53 and Sp1, supposed to play a role in the regulation of hRFC, suggest that regulation of hRFC expression in fetal life by these proteins is highly unlikely, at least by changes in their protein level.
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6
Total citations:
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Citations from 2024:
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(16.67%)
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GOST
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Lubec G. et al. Increased expression of human reduced folate carrier in fetal Down syndrome brain // Advances in Down Syndrome Research. 2003. Vol. 67. pp. 95-103.
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Lubec G., Bajo M., Cheon M. S., Bajova H., Matherly L. H. Increased expression of human reduced folate carrier in fetal Down syndrome brain // Advances in Down Syndrome Research. 2003. Vol. 67. pp. 95-103.
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TY - GENERIC
DO - 10.1007/978-3-7091-6721-2_8
UR - https://doi.org/10.1007/978-3-7091-6721-2_8
TI - Increased expression of human reduced folate carrier in fetal Down syndrome brain
T2 - Advances in Down Syndrome Research
AU - Lubec, G
AU - Bajo, M
AU - Cheon, M S
AU - Bajova, H.
AU - Matherly, L H
PY - 2003
DA - 2003/01/01
PB - Springer Nature
SP - 95-103
IS - 67
PMID - 15068242
SN - 0303-6995
ER -
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@incollection{2003_Lubec,
author = {G Lubec and M Bajo and M S Cheon and H. Bajova and L H Matherly},
title = {Increased expression of human reduced folate carrier in fetal Down syndrome brain},
publisher = {Springer Nature},
year = {2003},
number = {67},
pages = {95--103},
month = {jan}
}