Open Access
Overview of Histone Modification
Тип публикации: Book Chapter
Дата публикации: 2020-11-07
scimago Q3
SJR: 0.371
CiteScore: 4.5
Impact factor: 3.65
ISSN: 00652598, 22148019
PubMed ID:
33155134
Краткое описание
Epigenetics is the epi-information beyond the DNA sequence that can be inherited from parents to offspring. From years of studies, people have found that histone modifications, DNA methylation, and RNA-based mechanism are the main means of epigenetic control. In this chapter, we will focus on the general introductions of epigenetics, which is important in the regulation of chromatin structure and gene expression. With the development and expansion of high-throughput sequencing, various mutations of epigenetic regulators have been identified and proven to be the drivers of tumorigenesis. Epigenetic alterations are used to diagnose individual patients more accurately and specifically. Several drugs, which are targeting epigenetic changes, have been developed to treat patients regarding the awareness of precision medicine. Emerging researches are connecting the epigenetics and cancers together in the molecular mechanism exploration and the development of druggable targets.
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378
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378
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ГОСТ |
RIS |
BibTex
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ГОСТ
Скопировать
Zhang Y. et al. Overview of Histone Modification // Advances in Experimental Medicine and Biology. 2020. Vol. 1283. pp. 1-16.
ГОСТ со всеми авторами (до 50)
Скопировать
Zhang Y., Sun Z., Jia J., Du T., Zhang N., TANG Y., Fang Y., Fang Dong Overview of Histone Modification // Advances in Experimental Medicine and Biology. 2020. Vol. 1283. pp. 1-16.
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RIS
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TY - GENERIC
DO - 10.1007/978-981-15-8104-5_1
UR - https://doi.org/10.1007/978-981-15-8104-5_1
TI - Overview of Histone Modification
T2 - Advances in Experimental Medicine and Biology
AU - Zhang, Yanjun
AU - Sun, Zhongxing
AU - Jia, Junqi
AU - Du, Tianjiao
AU - Zhang, Nachuan
AU - TANG, YIN
AU - Fang, Yuan
AU - Fang Dong
PY - 2020
DA - 2020/11/07
PB - Springer Nature
SP - 1-16
VL - 1283
PMID - 33155134
SN - 0065-2598
SN - 2214-8019
ER -
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BibTex (до 50 авторов)
Скопировать
@incollection{2020_Zhang,
author = {Yanjun Zhang and Zhongxing Sun and Junqi Jia and Tianjiao Du and Nachuan Zhang and YIN TANG and Yuan Fang and Fang Dong},
title = {Overview of Histone Modification},
publisher = {Springer Nature},
year = {2020},
volume = {1283},
pages = {1--16},
month = {nov}
}