Open Access
Encapsulated Hsp70 decreases endotoxin-induced production of ROS and TNF alpha in human phagocytes
M M Yurinskaya
1, 2
,
O Yu Kochetkova
2, 3
,
L.I. Shabarchina
3
,
O Yu Antonova
2
,
A V Suslikov
4
,
Evgenev M B
1, 2
,
M G Vinokurov
2
1
Publication type: Journal Article
Publication date: 2016-10-26
scimago Q2
wos Q3
SJR: 0.876
CiteScore: 6.7
Impact factor: 3.2
ISSN: 13558145, 14661268
PubMed ID:
27783274
Biochemistry
Cell Biology
Abstract
Human heat shock protein Hsp70 was experimentally inserted into polyelectrolyte microcapsules. Encapsulated recombinant Hsp70 was studied in terms of its effects on neutrophil apoptosis, the production of reactive oxygen species, and the secretion of tumor necrosis factor alpha by promonocytic THP-1 cells. It was found that encapsulated Hsp70 effectively inhibits neutrophil apoptosis, unlike free exogenous protein used in solution. In THP-1 cells, encapsulated and free Hsp70 reduced LPS-induced tumor necrosis factor alpha production with a similar efficiency. Encapsulated Hsp70 reduces LPS-induced reactive oxygen species production by neutrophils in the course of its release from the microcapsules but not as much as free Hsp70. Thus, the polyelectrolyte microcapsules can be used as containers for the effective delivery of Hsp70 to neutrophils and monocytes to significantly improve the functioning of the innate immune system.
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GOST
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Yurinskaya M. M. et al. Encapsulated Hsp70 decreases endotoxin-induced production of ROS and TNF alpha in human phagocytes // Cell Stress and Chaperones. 2016. Vol. 22. No. 1. pp. 163-171.
GOST all authors (up to 50)
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Yurinskaya M. M., Kochetkova O. Yu., Shabarchina L., Antonova O. Yu., Suslikov A. V., M B E., Vinokurov M. G. Encapsulated Hsp70 decreases endotoxin-induced production of ROS and TNF alpha in human phagocytes // Cell Stress and Chaperones. 2016. Vol. 22. No. 1. pp. 163-171.
Cite this
RIS
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TY - JOUR
DO - 10.1007/S12192-016-0743-Z
UR - https://doi.org/10.1007/S12192-016-0743-Z
TI - Encapsulated Hsp70 decreases endotoxin-induced production of ROS and TNF alpha in human phagocytes
T2 - Cell Stress and Chaperones
AU - Yurinskaya, M M
AU - Kochetkova, O Yu
AU - Shabarchina, L.I.
AU - Antonova, O Yu
AU - Suslikov, A V
AU - M B, Evgenev
AU - Vinokurov, M G
PY - 2016
DA - 2016/10/26
PB - Springer Nature
SP - 163-171
IS - 1
VL - 22
PMID - 27783274
SN - 1355-8145
SN - 1466-1268
ER -
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BibTex (up to 50 authors)
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@article{2016_Yurinskaya,
author = {M M Yurinskaya and O Yu Kochetkova and L.I. Shabarchina and O Yu Antonova and A V Suslikov and Evgenev M B and M G Vinokurov},
title = {Encapsulated Hsp70 decreases endotoxin-induced production of ROS and TNF alpha in human phagocytes},
journal = {Cell Stress and Chaperones},
year = {2016},
volume = {22},
publisher = {Springer Nature},
month = {oct},
url = {https://doi.org/10.1007/S12192-016-0743-Z},
number = {1},
pages = {163--171},
doi = {10.1007/S12192-016-0743-Z}
}
Cite this
MLA
Copy
Yurinskaya, M. M., et al. “Encapsulated Hsp70 decreases endotoxin-induced production of ROS and TNF alpha in human phagocytes.” Cell Stress and Chaperones, vol. 22, no. 1, Oct. 2016, pp. 163-171. https://doi.org/10.1007/S12192-016-0743-Z.
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