The Japanese Journal of Human Genetics, volume 39, issue 3, pages 337-343

Fluorescencein situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1

KIYOSHI INOUE ¹

Johji Inazawa ²

Yasuhiko SUZUKI ¹

Tsutomu Shimada ¹

Hiroshi Yamazaki ¹

F. Peter GUENGERICH ³

Tatsuo ABE ²

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Osaka Prefectural Institute of Public health, Osaka, Japan |

Department of Hygiene, Kyoto Prefectural University of Medicine, Kyoto, Japan |

Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, USA |

Publication type: Journal Article

Publication date: 1994-09-01

Springer Nature

Journal: The Japanese Journal of Human Genetics

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CiteScore: —

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ISSN: 00215074, 09168478

DOI: 10.1007/bf01874052

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PubMed ID: 7841444

Genetics (clinical)

Abstract

Chromosomal localization of three human cytochrome P450 genes belonging to the CYP2C subfamily (CYP2C8, 2C9, and 2C10) was identified by fluorescencein situ hybridization (FISH). An original MP-8 clone was used as a DNA probe for the assignment of the CYP2C10 gene, while two cDNA probes, a 1.37 kb fragment of CYP2C8 and a 1.19 kb fragment (MP-20 and MP-4 clones, respectively) by polymerase chain reaction using a single human liver cDNA library. The results showed that three human CYP2C8, 2C9, and 2C10 cDNAs were located at the same subchromosomal region, 10q24.1.

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Springer Nature

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The Japanese Journal of Human Genetics

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—

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—

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—

ISSN

00215074 (Print)

09168478

Fluorescencein situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1

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