Open Access

Cellular and Molecular Life Sciences, volume 73, issue 8, pages 1659-1670

Reactivation of telomerase in cancer

Akincilar Semih Can ^{1, 2}

Unal Bilal ^{1, 2}

Tergaonkar Vinay ^{1, 2, 3}

Hide authors affiliations Show authors affiliations: 3 affiliations

Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore, Singapore |

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore |

Centre for Cancer Biology, University of South Australia and Sa Pathology, Adelaide, Australia |

Publication type: Journal Article

Publication date: 2016-02-04

Springer Nature

Journal: Cellular and Molecular Life Sciences

Quartile SCImago

Quartile WOS

Impact factor: 8

ISSN: 1420682X, 14209071

DOI: 10.1007/s00018-016-2146-9

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PubMed ID: 26846696

Molecular Biology

Pharmacology

Cell Biology

Molecular Medicine

Cellular and Molecular Neuroscience

Abstract

Activation of telomerase is a critical step in the development of about 85 % of human cancers. Levels of Tert, which encodes the reverse transcriptase subunit of telomerase, are limiting in normal somatic cells. Tert is subjected to transcriptional, post-transcriptional and epigenetic regulation, but the precise mechanism of how telomerase is re-activated in cancer cells is poorly understood. Reactivation of the Tert promoter involves multiple changes which evolve during cancer progression including mutations and chromosomal re-arrangements. Newly described non-coding mutations in the Tert promoter region of many cancer cells (19 %) in two key positions, C250T and C228T, have added another layer of complexity to telomerase reactivation. These mutations create novel consensus sequences for transcription factors which can enhance Tert expression. In this review, we will discuss gene structure and function of Tert and provide insights into the mechanisms of Tert reactivation in cancers, highlighting the contribution of recently identified Tert promoter mutations.

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Citations by journals

	1 2 3 4 5 6 7
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 7, 5.07% International Journal of Molecular Sciences 7 publications, 5.07%
Genes	Genes, 4, 2.9% Genes 4 publications, 2.9%
Cancers	Cancers, 3, 2.17% Cancers 3 publications, 2.17%
Scientific Reports	Scientific Reports, 3, 2.17% Scientific Reports 3 publications, 2.17%
PLoS ONE	PLoS ONE, 3, 2.17% PLoS ONE 3 publications, 2.17%
Proceedings of the National Academy of Sciences of the United States of America	Proceedings of the National Academy of Sciences of the United States of America, 3, 2.17% Proceedings of the National Academy of Sciences of the United States of America 3 publications, 2.17%
Frontiers in Cell and Developmental Biology	Frontiers in Cell and Developmental Biology, 2, 1.45% Frontiers in Cell and Developmental Biology 2 publications, 1.45%
Oncology Reports	Oncology Reports, 2, 1.45% Oncology Reports 2 publications, 1.45%
Medicine (United States)	Medicine (United States), 2, 1.45% Medicine (United States) 2 publications, 1.45%
Journal of Clinical Medicine	Journal of Clinical Medicine, 2, 1.45% Journal of Clinical Medicine 2 publications, 1.45%
Biomedicines	Biomedicines, 2, 1.45% Biomedicines 2 publications, 1.45%
Frontiers in Immunology	Frontiers in Immunology, 2, 1.45% Frontiers in Immunology 2 publications, 1.45%
Frontiers in Oncology	Frontiers in Oncology, 2, 1.45% Frontiers in Oncology 2 publications, 1.45%
Endocrine Pathology	Endocrine Pathology, 2, 1.45% Endocrine Pathology 2 publications, 1.45%
Cancer and Metastasis Reviews	Cancer and Metastasis Reviews, 2, 1.45% Cancer and Metastasis Reviews 2 publications, 1.45%
Child's Nervous System	Child's Nervous System, 2, 1.45% Child's Nervous System 2 publications, 1.45%
Sensors and Actuators, B: Chemical	Sensors and Actuators, B: Chemical, 2, 1.45% Sensors and Actuators, B: Chemical 2 publications, 1.45%
Analytical Chemistry	Analytical Chemistry, 2, 1.45% Analytical Chemistry 2 publications, 1.45%
Endocrine-Related Cancer	Endocrine-Related Cancer, 1, 0.72% Endocrine-Related Cancer 1 publication, 0.72%
European Respiratory Journal	European Respiratory Journal, 1, 0.72% European Respiratory Journal 1 publication, 0.72%
Future Oncology	Future Oncology, 1, 0.72% Future Oncology 1 publication, 0.72%
Oncotarget	Oncotarget, 1, 0.72% Oncotarget 1 publication, 0.72%
Tumor Biology	Tumor Biology, 1, 0.72% Tumor Biology 1 publication, 0.72%
Oncology Letters	Oncology Letters, 1, 0.72% Oncology Letters 1 publication, 0.72%
International Journal of Molecular Medicine	International Journal of Molecular Medicine, 1, 0.72% International Journal of Molecular Medicine 1 publication, 0.72%
Arteriosclerosis, Thrombosis, and Vascular Biology	Arteriosclerosis, Thrombosis, and Vascular Biology, 1, 0.72% Arteriosclerosis, Thrombosis, and Vascular Biology 1 publication, 0.72%
Melanoma Research	Melanoma Research, 1, 0.72% Melanoma Research 1 publication, 0.72%
Applied Immunohistochemistry and Molecular Morphology	Applied Immunohistochemistry and Molecular Morphology, 1, 0.72% Applied Immunohistochemistry and Molecular Morphology 1 publication, 0.72%
International Journal of Gynecological Pathology	International Journal of Gynecological Pathology, 1, 0.72% International Journal of Gynecological Pathology 1 publication, 0.72%
	1 2 3 4 5 6 7

Citations by publishers

	5 10 15 20 25
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 22, 15.94% Multidisciplinary Digital Publishing Institute (MDPI) 22 publications, 15.94%
Springer Nature	Springer Nature, 22, 15.94% Springer Nature 22 publications, 15.94%
Elsevier	Elsevier, 22, 15.94% Elsevier 22 publications, 15.94%
Wiley	Wiley, 12, 8.7% Wiley 12 publications, 8.7%
Frontiers Media S.A.	Frontiers Media S.A., 8, 5.8% Frontiers Media S.A. 8 publications, 5.8%
Wolters Kluwer Health	Wolters Kluwer Health, 6, 4.35% Wolters Kluwer Health 6 publications, 4.35%
Spandidos Publications	Spandidos Publications, 4, 2.9% Spandidos Publications 4 publications, 2.9%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 3, 2.17% Public Library of Science (PLoS) 3 publications, 2.17%
American Chemical Society (ACS)	American Chemical Society (ACS), 3, 2.17% American Chemical Society (ACS) 3 publications, 2.17%
Oxford University Press	Oxford University Press, 3, 2.17% Oxford University Press 3 publications, 2.17%
Hindawi Limited	Hindawi Limited, 3, 2.17% Hindawi Limited 3 publications, 2.17%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 3, 2.17% Proceedings of the National Academy of Sciences (PNAS) 3 publications, 2.17%
SAGE	SAGE, 2, 1.45% SAGE 2 publications, 1.45%
BMJ	BMJ, 2, 1.45% BMJ 2 publications, 1.45%
Bioscientifica	Bioscientifica, 1, 0.72% Bioscientifica 1 publication, 0.72%
European Respiratory Society (ERS)	European Respiratory Society (ERS), 1, 0.72% European Respiratory Society (ERS) 1 publication, 0.72%
Future Medicine	Future Medicine, 1, 0.72% Future Medicine 1 publication, 0.72%
Impact Journals	Impact Journals, 1, 0.72% Impact Journals 1 publication, 0.72%
Baishideng Publishing Group	Baishideng Publishing Group, 1, 0.72% Baishideng Publishing Group 1 publication, 0.72%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 1, 0.72% American Society for Biochemistry and Molecular Biology 1 publication, 0.72%
Taylor & Francis	Taylor & Francis, 1, 0.72% Taylor & Francis 1 publication, 0.72%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 1, 0.72% American Association for the Advancement of Science (AAAS) 1 publication, 0.72%
Medknow Publications	Medknow Publications, 1, 0.72% Medknow Publications 1 publication, 0.72%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 1, 0.72% American Association for Cancer Research (AACR) 1 publication, 0.72%
Thieme	Thieme, 1, 0.72% Thieme 1 publication, 0.72%
Pleiades Publishing	Pleiades Publishing, 1, 0.72% Pleiades Publishing 1 publication, 0.72%
Dove Medical Press	Dove Medical Press, 1, 0.72% Dove Medical Press 1 publication, 0.72%
Bentham Science	Bentham Science, 1, 0.72% Bentham Science 1 publication, 0.72%
	5 10 15 20 25

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Akincilar S. C. et al. Reactivation of telomerase in cancer // Cellular and Molecular Life Sciences. 2016. Vol. 73. No. 8. pp. 1659-1670.

GOST all authors (up to 50) Copy

Akincilar S. C., Unal B., Tergaonkar V. Reactivation of telomerase in cancer // Cellular and Molecular Life Sciences. 2016. Vol. 73. No. 8. pp. 1659-1670.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1007/s00018-016-2146-9

UR - https://doi.org/10.1007%2Fs00018-016-2146-9

TI - Reactivation of telomerase in cancer

T2 - Cellular and Molecular Life Sciences

AU - Akincilar, Semih Can

AU - Unal, Bilal

AU - Tergaonkar, Vinay

PY - 2016

DA - 2016/02/04 00:00:00

PB - Springer Nature

SP - 1659-1670

IS - 8

VL - 73

PMID - 26846696

SN - 1420-682X

SN - 1420-9071

ER -

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BibTex Copy

@article{2016_Akincilar,

author = {Semih Can Akincilar and Bilal Unal and Vinay Tergaonkar},

title = {Reactivation of telomerase in cancer},

journal = {Cellular and Molecular Life Sciences},

year = {2016},

volume = {73},

publisher = {Springer Nature},

month = {feb},

url = {https://doi.org/10.1007%2Fs00018-016-2146-9},

number = {8},

pages = {1659--1670},

doi = {10.1007/s00018-016-2146-9}

}

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Akincilar, Semih Can, et al. “Reactivation of telomerase in cancer.” Cellular and Molecular Life Sciences, vol. 73, no. 8, Feb. 2016, pp. 1659-1670. https://doi.org/10.1007%2Fs00018-016-2146-9.

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Springer Nature

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Cellular and Molecular Life Sciences

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1420682X (Print)
14209071 (Electronic)