Synthesis and analgesic activity of new heterocyclic compounds derived from monoterpenoids
Тип публикации: Journal Article
Дата публикации: 2012-11-09
scimago Q2
wos Q3
БС2
SJR: 0.470
CiteScore: 5.1
Impact factor: 3.1
ISSN: 10542523, 15548120
Organic Chemistry
General Pharmacology, Toxicology and Pharmaceutics
Краткое описание
A set of new heterocyclic compounds with different types of framework, including a new type of framework, were synthesized by reactions of verbenol epoxide and (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol with aromatic aldehydes containing three methoxy groups. The analgesic activity of these substances was studied. Three compounds possessed considerable activity in vivo in the acetic acid-induced writhing test. (2S,4R,4aR,8S,8aR)-4,7-Dimethyl-2-(2,4,5-trimethoxyphenyl)-3,4,4a,5,8,8a-hexahydro-2H-4,8-epoxychromene exhibited high analgesic activity in both acetic acid-induced writhing and hot plate tests; its selectivity index IS50 exceeded 60.
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Mikhalchenko O. et al. Synthesis and analgesic activity of new heterocyclic compounds derived from monoterpenoids // Medicinal Chemistry Research. 2012. Vol. 22. No. 6. pp. 3026-3034.
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Mikhalchenko O., Ilina I., Pavlova A., Morozova E., Korchagina D., Tolstikova T., Pokushalov E., Volcho K., Salakhutdinov N. Synthesis and analgesic activity of new heterocyclic compounds derived from monoterpenoids // Medicinal Chemistry Research. 2012. Vol. 22. No. 6. pp. 3026-3034.
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TY - JOUR
DO - 10.1007/s00044-012-0310-9
UR - https://doi.org/10.1007/s00044-012-0310-9
TI - Synthesis and analgesic activity of new heterocyclic compounds derived from monoterpenoids
T2 - Medicinal Chemistry Research
AU - Mikhalchenko, Oksana
AU - Ilina, Irina
AU - Pavlova, Alla
AU - Morozova, Ekaterina
AU - Korchagina, Dina
AU - Tolstikova, Tatyana
AU - Pokushalov, Evgeny
AU - Volcho, Konstantin
AU - Salakhutdinov, Nariman
PY - 2012
DA - 2012/11/09
PB - Springer Nature
SP - 3026-3034
IS - 6
VL - 22
SN - 1054-2523
SN - 1554-8120
ER -
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@article{2012_Mikhalchenko,
author = {Oksana Mikhalchenko and Irina Ilina and Alla Pavlova and Ekaterina Morozova and Dina Korchagina and Tatyana Tolstikova and Evgeny Pokushalov and Konstantin Volcho and Nariman Salakhutdinov},
title = {Synthesis and analgesic activity of new heterocyclic compounds derived from monoterpenoids},
journal = {Medicinal Chemistry Research},
year = {2012},
volume = {22},
publisher = {Springer Nature},
month = {nov},
url = {https://doi.org/10.1007/s00044-012-0310-9},
number = {6},
pages = {3026--3034},
doi = {10.1007/s00044-012-0310-9}
}
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MLA
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Mikhalchenko, Oksana, et al. “Synthesis and analgesic activity of new heterocyclic compounds derived from monoterpenoids.” Medicinal Chemistry Research, vol. 22, no. 6, Nov. 2012, pp. 3026-3034. https://doi.org/10.1007/s00044-012-0310-9.
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