Synthesis and analgesic activity of new heterocyclic compounds derived from monoterpenoids
Oksana Mikhalchenko
1
,
Irina Ilina
2
,
Alla Pavlova
2
,
Ekaterina Morozova
2
,
Dina Korchagina
2
,
Tatyana Tolstikova
2
,
Evgeny Pokushalov
3
,
3
State Research Institute of Circulation Pathology, Novosibirsk, Russian Federation
|
Publication type: Journal Article
Publication date: 2012-11-09
scimago Q2
wos Q3
SJR: 0.470
CiteScore: 5.1
Impact factor: 3.1
ISSN: 10542523, 15548120
Organic Chemistry
General Pharmacology, Toxicology and Pharmaceutics
Abstract
A set of new heterocyclic compounds with different types of framework, including a new type of framework, were synthesized by reactions of verbenol epoxide and (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol with aromatic aldehydes containing three methoxy groups. The analgesic activity of these substances was studied. Three compounds possessed considerable activity in vivo in the acetic acid-induced writhing test. (2S,4R,4aR,8S,8aR)-4,7-Dimethyl-2-(2,4,5-trimethoxyphenyl)-3,4,4a,5,8,8a-hexahydro-2H-4,8-epoxychromene exhibited high analgesic activity in both acetic acid-induced writhing and hot plate tests; its selectivity index IS50 exceeded 60.
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Total citations:
30
Citations from 2024:
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(10%)
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RIS |
BibTex |
MLA
Cite this
GOST
Copy
Mikhalchenko O. et al. Synthesis and analgesic activity of new heterocyclic compounds derived from monoterpenoids // Medicinal Chemistry Research. 2012. Vol. 22. No. 6. pp. 3026-3034.
GOST all authors (up to 50)
Copy
Mikhalchenko O., Ilina I., Pavlova A., Morozova E., Korchagina D., Tolstikova T., Pokushalov E., Volcho K., Salakhutdinov N. Synthesis and analgesic activity of new heterocyclic compounds derived from monoterpenoids // Medicinal Chemistry Research. 2012. Vol. 22. No. 6. pp. 3026-3034.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1007/s00044-012-0310-9
UR - https://doi.org/10.1007/s00044-012-0310-9
TI - Synthesis and analgesic activity of new heterocyclic compounds derived from monoterpenoids
T2 - Medicinal Chemistry Research
AU - Mikhalchenko, Oksana
AU - Ilina, Irina
AU - Pavlova, Alla
AU - Morozova, Ekaterina
AU - Korchagina, Dina
AU - Tolstikova, Tatyana
AU - Pokushalov, Evgeny
AU - Volcho, Konstantin
AU - Salakhutdinov, Nariman
PY - 2012
DA - 2012/11/09
PB - Springer Nature
SP - 3026-3034
IS - 6
VL - 22
SN - 1054-2523
SN - 1554-8120
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2012_Mikhalchenko,
author = {Oksana Mikhalchenko and Irina Ilina and Alla Pavlova and Ekaterina Morozova and Dina Korchagina and Tatyana Tolstikova and Evgeny Pokushalov and Konstantin Volcho and Nariman Salakhutdinov},
title = {Synthesis and analgesic activity of new heterocyclic compounds derived from monoterpenoids},
journal = {Medicinal Chemistry Research},
year = {2012},
volume = {22},
publisher = {Springer Nature},
month = {nov},
url = {https://doi.org/10.1007/s00044-012-0310-9},
number = {6},
pages = {3026--3034},
doi = {10.1007/s00044-012-0310-9}
}
Cite this
MLA
Copy
Mikhalchenko, Oksana, et al. “Synthesis and analgesic activity of new heterocyclic compounds derived from monoterpenoids.” Medicinal Chemistry Research, vol. 22, no. 6, Nov. 2012, pp. 3026-3034. https://doi.org/10.1007/s00044-012-0310-9.