Synthesis and antimicrobial evaluation of novel substituted pyrimidine scaffold
Тип публикации: Journal Article
Дата публикации: 2013-05-07
scimago Q2
wos Q3
БС2
SJR: 0.47
CiteScore: 5.1
Impact factor: 3.1
ISSN: 10542523, 15548120
Organic Chemistry
General Pharmacology, Toxicology and Pharmaceutics
Краткое описание
Synthesis and biological evaluation of substituted pyrimidine derivatives containing 4-amino and 5-cyano substituted derivatives are described. Biginelli typed three component reactions between an aldehyde, malononitrile, and a urea constituent give a rapid facile pyrimidine ring. The constitution of the products has been delineated by elemental analysis and spectral analysis. The products were assayed for their in vitro biological assay antibacterial activity against S. pyogenes MTCC-442, S. aureus MTCC-96, E. coli MTCC-443, and B. subtilis MTCC-441 bacterial strain and antifungal activity against Aspergillus niger MTCC-282 and Candida albicans MTCC-227 at different concentrations, which compared with Ampicillin, Chloramphenicol, Ciprofloxacin, Norfloxacin, and Griseofulvin as standard drug which are presented.
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12
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12
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Ghodasara H. B. et al. Synthesis and antimicrobial evaluation of novel substituted pyrimidine scaffold // Medicinal Chemistry Research. 2013. Vol. 22. No. 12. pp. 6121-6128.
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Ghodasara H. B., Trivedi A. R., Kataria V. B., Patel B. G., Shah V. H. Synthesis and antimicrobial evaluation of novel substituted pyrimidine scaffold // Medicinal Chemistry Research. 2013. Vol. 22. No. 12. pp. 6121-6128.
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TY - JOUR
DO - 10.1007/s00044-013-0596-2
UR - https://doi.org/10.1007/s00044-013-0596-2
TI - Synthesis and antimicrobial evaluation of novel substituted pyrimidine scaffold
T2 - Medicinal Chemistry Research
AU - Ghodasara, Hardik B
AU - Trivedi, Amit R
AU - Kataria, Vipul B
AU - Patel, Bharat G.
AU - Shah, Viresh H
PY - 2013
DA - 2013/05/07
PB - Springer Nature
SP - 6121-6128
IS - 12
VL - 22
SN - 1054-2523
SN - 1554-8120
ER -
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@article{2013_Ghodasara,
author = {Hardik B Ghodasara and Amit R Trivedi and Vipul B Kataria and Bharat G. Patel and Viresh H Shah},
title = {Synthesis and antimicrobial evaluation of novel substituted pyrimidine scaffold},
journal = {Medicinal Chemistry Research},
year = {2013},
volume = {22},
publisher = {Springer Nature},
month = {may},
url = {https://doi.org/10.1007/s00044-013-0596-2},
number = {12},
pages = {6121--6128},
doi = {10.1007/s00044-013-0596-2}
}
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MLA
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Ghodasara, Hardik B., et al. “Synthesis and antimicrobial evaluation of novel substituted pyrimidine scaffold.” Medicinal Chemistry Research, vol. 22, no. 12, May. 2013, pp. 6121-6128. https://doi.org/10.1007/s00044-013-0596-2.