Synthesis and analgesic activity of monoterpenoid-derived 2-aryl-4,4,7-trimethyl-4a,5,8,8a-tetrahydro-4H-benzo[d][1,3]dioxin-8-ols
Svetlana Kurbakova
1
,
Irina Ilina
1
,
Alla Pavlova
1
,
Dina Korchagina
1
,
Olga Yarovaya
1
,
Tatyana Tolstikova
1
,
Publication type: Journal Article
Publication date: 2013-09-12
scimago Q2
wos Q3
SJR: 0.470
CiteScore: 5.1
Impact factor: 3.1
ISSN: 10542523, 15548120
Organic Chemistry
General Pharmacology, Toxicology and Pharmaceutics
Abstract
A new series of chiral heterocyclic compounds with frameworks of different types were synthesized by reactions of verbenol epoxide with aromatic aldehydes in the presence of montmorillonite clay. The analgesic activity of compounds with frameworks of 2-aryl-4,4,7-trimethyl-4a,5,8,8a-tetrahydro-4H-benzo[d][1,3]dioxin-8-ol type was studied in vivo. The majority of these compounds showed a significant analgesic activity in the acetic acid-induced writhing test; two compounds also showed analgesic activity in the hot-plate test. ED50 in acetic acid-induced writhing test for compound where aryl is 4-chlorophenyl substituent was determined to be 4.5 mg/kg. Compound with 4-nitrophenyl substituent demonstrated high analgesic activity in both tests.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
4
|
|
|
Medicinal Chemistry Research
4 publications, 33.33%
|
|
|
Russian Chemical Reviews
2 publications, 16.67%
|
|
|
Journal of Molecular Catalysis A Chemical
2 publications, 16.67%
|
|
|
Chinese Journal of Catalysis
1 publication, 8.33%
|
|
|
Catalysis Today
1 publication, 8.33%
|
|
|
Molecular Catalysis
1 publication, 8.33%
|
|
|
Helvetica Chimica Acta
1 publication, 8.33%
|
|
|
1
2
3
4
|
Publishers
|
1
2
3
4
5
|
|
|
Elsevier
5 publications, 41.67%
|
|
|
Springer Nature
4 publications, 33.33%
|
|
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
2 publications, 16.67%
|
|
|
Wiley
1 publication, 8.33%
|
|
|
1
2
3
4
5
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
12
Total citations:
12
Citations from 2024:
1
(8.33%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Kurbakova S. et al. Synthesis and analgesic activity of monoterpenoid-derived 2-aryl-4,4,7-trimethyl-4a,5,8,8a-tetrahydro-4H-benzo[d][1,3]dioxin-8-ols // Medicinal Chemistry Research. 2013. Vol. 23. No. 4. pp. 1709-1717.
GOST all authors (up to 50)
Copy
Kurbakova S., Ilina I., Pavlova A., Korchagina D., Yarovaya O., Tolstikova T., Volcho K., Salakhutdinov N. Synthesis and analgesic activity of monoterpenoid-derived 2-aryl-4,4,7-trimethyl-4a,5,8,8a-tetrahydro-4H-benzo[d][1,3]dioxin-8-ols // Medicinal Chemistry Research. 2013. Vol. 23. No. 4. pp. 1709-1717.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1007/s00044-013-0772-4
UR - https://doi.org/10.1007/s00044-013-0772-4
TI - Synthesis and analgesic activity of monoterpenoid-derived 2-aryl-4,4,7-trimethyl-4a,5,8,8a-tetrahydro-4H-benzo[d][1,3]dioxin-8-ols
T2 - Medicinal Chemistry Research
AU - Kurbakova, Svetlana
AU - Ilina, Irina
AU - Pavlova, Alla
AU - Korchagina, Dina
AU - Yarovaya, Olga
AU - Tolstikova, Tatyana
AU - Volcho, Konstantin
AU - Salakhutdinov, Nariman
PY - 2013
DA - 2013/09/12
PB - Springer Nature
SP - 1709-1717
IS - 4
VL - 23
SN - 1054-2523
SN - 1554-8120
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2013_Kurbakova,
author = {Svetlana Kurbakova and Irina Ilina and Alla Pavlova and Dina Korchagina and Olga Yarovaya and Tatyana Tolstikova and Konstantin Volcho and Nariman Salakhutdinov},
title = {Synthesis and analgesic activity of monoterpenoid-derived 2-aryl-4,4,7-trimethyl-4a,5,8,8a-tetrahydro-4H-benzo[d][1,3]dioxin-8-ols},
journal = {Medicinal Chemistry Research},
year = {2013},
volume = {23},
publisher = {Springer Nature},
month = {sep},
url = {https://doi.org/10.1007/s00044-013-0772-4},
number = {4},
pages = {1709--1717},
doi = {10.1007/s00044-013-0772-4}
}
Cite this
MLA
Copy
Kurbakova, Svetlana, et al. “Synthesis and analgesic activity of monoterpenoid-derived 2-aryl-4,4,7-trimethyl-4a,5,8,8a-tetrahydro-4H-benzo[d][1,3]dioxin-8-ols.” Medicinal Chemistry Research, vol. 23, no. 4, Sep. 2013, pp. 1709-1717. https://doi.org/10.1007/s00044-013-0772-4.