Medicinal Chemistry Research, volume 24, issue 9, pages 3516-3528
Design, synthesis and anticancer activity of functionalized spiro-quinolines with barbituric and thiobarbituric acids
Bhaskarachar Ravi Kiran
1
,
Vijayakumar G Revanasiddappa
1
,
Subramanya Hegde
2
,
Janardhana P Balakrishna
3
,
Suman Y Reddy
4
2
Department of Chemistry, Government Science College, Bangalore, India
|
3
Stellixir Biotech Pvt Ltd., Bangalore, India
|
Publication type: Journal Article
Publication date: 2015-07-10
Journal:
Medicinal Chemistry Research
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 2.6
ISSN: 10542523, 15548120
Organic Chemistry
General Pharmacology, Toxicology and Pharmaceutics
Abstract
A new series of spiro-quinoline compounds have been accomplished by the reaction of barbituric acid or thiobarbituric acid with derivatives of benzisoxazole-5-carbaldehyde or 2-substituted benzaldehyde. These compounds were evaluated for their in vitro cytotoxicity on two mammalian cancer cell lines MCF-7 and KB. The compounds exhibit cytotoxicity against these cell lines in micromolar range. Among the series of compounds, 11(a–j) particularly 11b and 11e showed relatively good activity against both the tested cell lines. Compound 11b was found to exhibit the highest cytotoxic activity with IC50 value 90.2 µM for MCF-7 and 49.8 µM for KB cell line. Flow cytometric analysis study confirmed that these molecules induced cytotoxicity via apoptosis.
Top-30
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1 publication, 4.55%
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1 publication, 4.55%
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1 publication, 4.55%
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1 publication, 4.55%
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1 publication, 4.55%
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1 publication, 4.55%
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1 publication, 4.55%
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Citations by publishers
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5
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Royal Society of Chemistry (RSC)
5 publications, 22.73%
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Elsevier
4 publications, 18.18%
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Bentham Science
3 publications, 13.64%
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Wiley
3 publications, 13.64%
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Beilstein-Institut
1 publication, 4.55%
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1 publication, 4.55%
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 4.55%
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American Chemical Society (ACS)
1 publication, 4.55%
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Taylor & Francis
1 publication, 4.55%
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The Japan Institute of Heterocyclic Chemistry
1 publication, 4.55%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 4.55%
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Ravi Kiran B. et al. Design, synthesis and anticancer activity of functionalized spiro-quinolines with barbituric and thiobarbituric acids // Medicinal Chemistry Research. 2015. Vol. 24. No. 9. pp. 3516-3528.
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Ravi Kiran B., Revanasiddappa V. G., Hegde S., Balakrishna J. P., Reddy S. Y. Design, synthesis and anticancer activity of functionalized spiro-quinolines with barbituric and thiobarbituric acids // Medicinal Chemistry Research. 2015. Vol. 24. No. 9. pp. 3516-3528.
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TY - JOUR
DO - 10.1007/s00044-015-1408-7
UR - https://doi.org/10.1007/s00044-015-1408-7
TI - Design, synthesis and anticancer activity of functionalized spiro-quinolines with barbituric and thiobarbituric acids
T2 - Medicinal Chemistry Research
AU - Ravi Kiran, Bhaskarachar
AU - Revanasiddappa, Vijayakumar G
AU - Hegde, Subramanya
AU - Balakrishna, Janardhana P
AU - Reddy, Suman Y
PY - 2015
DA - 2015/07/10 00:00:00
PB - Springer Nature
SP - 3516-3528
IS - 9
VL - 24
SN - 1054-2523
SN - 1554-8120
ER -
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@article{2015_Ravi Kiran,
author = {Bhaskarachar Ravi Kiran and Vijayakumar G Revanasiddappa and Subramanya Hegde and Janardhana P Balakrishna and Suman Y Reddy},
title = {Design, synthesis and anticancer activity of functionalized spiro-quinolines with barbituric and thiobarbituric acids},
journal = {Medicinal Chemistry Research},
year = {2015},
volume = {24},
publisher = {Springer Nature},
month = {jul},
url = {https://doi.org/10.1007/s00044-015-1408-7},
number = {9},
pages = {3516--3528},
doi = {10.1007/s00044-015-1408-7}
}
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MLA
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Ravi Kiran, Bhaskarachar, et al. “Design, synthesis and anticancer activity of functionalized spiro-quinolines with barbituric and thiobarbituric acids.” Medicinal Chemistry Research, vol. 24, no. 9, Jul. 2015, pp. 3516-3528. https://doi.org/10.1007/s00044-015-1408-7.