Medicinal Chemistry Research

, volume 24 , issue 12 , pages 4146-4156

Synthesis and analgesic activity of new compounds combining azaadamantane and monoterpene moieties

Konstantin Ponomarev ¹

Alla Pavlova ¹

Evgeniy Suslov ¹

Oleg Ardashov ^{1, 2}

Dina Korchagina ¹

Andrej Nefedov ¹

Tatyana Tolstikova ¹

Konstantin Volcho ^{1, 2}

Nariman Salakhutdinov ^{1, 2}

Hide authors affiliations Show authors affiliations: 2 affiliations

Siberian Branch, Novosibirsk Institute of Organic Chemistry, Russian Academy of Sciences, Novosibirsk, Russian Federation |

Novosibirsk State University, Novosibirsk, Russian Federation |

Publication type: Journal Article

Publication date: 2015-09-09

Springer Nature

Medicinal Chemistry Research

scimago Q2

wos Q3

SJR: 0.470

CiteScore: 5.1

Impact factor: 3.1

ISSN: 10542523, 15548120

DOI: 10.1007/s00044-015-1464-z

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Organic Chemistry

General Pharmacology, Toxicology and Pharmaceutics

Abstract

Synthesis of new compounds that combine the diazaadamantane and monoterpenoid moieties was carried out based on the reaction between dimethylbispidinone and monoterpene-derived aldehydes. Investigation of the analgesic activity of the obtained products revealed that compound 5a synthesized from (−)-myrtenal had a higher efficacy compared with the reference drug, diclofenac sodium, in the acetic acid-induced writhing and hot plate tests. Compound 5a exhibits a low acute toxicity and does not cause damage to the gastric mucosa, and its analgesic effect is, at least partially, mediated by the cannabinoid system involving CB1 receptors.

Found

12 citations

Volcho Konstantin

DSc in Chemistry, professor of the Russian Academy of Sciences

279 publications, 3 898 citations, 65 reviews

h-index: 31

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the Russian Academy of Sciences

4 citations

Yarovaya Olga

PhD in Chemistry

117 publications, 1 801 citations, 14 reviews

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N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the Russian Academy of Sciences

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Luzina Olga

DSc in Chemistry

104 publications, 1 264 citations, 21 reviews

h-index: 21

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the Russian Academy of Sciences

Research interests

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Medicinal Chemistry

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2 citations

Vatsadze Sergey

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h-index: 20

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

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N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

Photochemistry Center

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h-index: 20

Smorodintsev Research Institute of Influenza

Research interests

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Virology

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34 publications, 401 citations

h-index: 13

Smorodintsev Research Institute of Influenza

1 citation

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44 publications, 625 citations

h-index: 14

Saint Petersburg State University

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224 publications, 2 599 citations

h-index: 26

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

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h-index: 22

North Caucasus Federal University

Kuban State University

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Zagidullin Almaz

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A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

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Chemistry of organic and organoelement compounds; chemistry of polymers; production of materials

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Aksenov Aleksandr

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North Caucasus Federal University

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Ural Federal University

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Filimonov Aleksandr

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Ural Federal University

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GOST Copy

Ponomarev K. et al. Synthesis and analgesic activity of new compounds combining azaadamantane and monoterpene moieties // Medicinal Chemistry Research. 2015. Vol. 24. No. 12. pp. 4146-4156.

GOST all authors (up to 50) Copy

Ponomarev K., Pavlova A., Suslov E., Ardashov O., Korchagina D., Nefedov A., Tolstikova T., Volcho K., Salakhutdinov N. Synthesis and analgesic activity of new compounds combining azaadamantane and monoterpene moieties // Medicinal Chemistry Research. 2015. Vol. 24. No. 12. pp. 4146-4156.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1007/s00044-015-1464-z

UR - https://doi.org/10.1007/s00044-015-1464-z

TI - Synthesis and analgesic activity of new compounds combining azaadamantane and monoterpene moieties

T2 - Medicinal Chemistry Research

AU - Ponomarev, Konstantin

AU - Pavlova, Alla

AU - Suslov, Evgeniy

AU - Ardashov, Oleg

AU - Korchagina, Dina

AU - Nefedov, Andrej

AU - Tolstikova, Tatyana

AU - Volcho, Konstantin

AU - Salakhutdinov, Nariman

PY - 2015

DA - 2015/09/09

PB - Springer Nature

SP - 4146-4156

IS - 12

VL - 24

SN - 1054-2523

SN - 1554-8120

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2015_Ponomarev,

author = {Konstantin Ponomarev and Alla Pavlova and Evgeniy Suslov and Oleg Ardashov and Dina Korchagina and Andrej Nefedov and Tatyana Tolstikova and Konstantin Volcho and Nariman Salakhutdinov},

title = {Synthesis and analgesic activity of new compounds combining azaadamantane and monoterpene moieties},

journal = {Medicinal Chemistry Research},

year = {2015},

volume = {24},

publisher = {Springer Nature},

month = {sep},

url = {https://doi.org/10.1007/s00044-015-1464-z},

number = {12},

pages = {4146--4156},

doi = {10.1007/s00044-015-1464-z}

}

MLA

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MLA Copy

Ponomarev, Konstantin, et al. “Synthesis and analgesic activity of new compounds combining azaadamantane and monoterpene moieties.” Medicinal Chemistry Research, vol. 24, no. 12, Sep. 2015, pp. 4146-4156. https://doi.org/10.1007/s00044-015-1464-z.

Publisher

Springer Nature

Journal

Medicinal Chemistry Research

scimago Q2

wos Q3

SJR

0.470

CiteScore

5.1

Impact factor

3.1

ISSN

10542523 (Print)

15548120 (Electronic)

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