Synthesis and analgesic activity of new compounds combining azaadamantane and monoterpene moieties
Тип публикации: Journal Article
Дата публикации: 2015-09-09
scimago Q2
wos Q3
БС2
SJR: 0.470
CiteScore: 5.1
Impact factor: 3.1
ISSN: 10542523, 15548120
Organic Chemistry
General Pharmacology, Toxicology and Pharmaceutics
Краткое описание
Synthesis of new compounds that combine the diazaadamantane and monoterpenoid moieties was carried out based on the reaction between dimethylbispidinone and monoterpene-derived aldehydes. Investigation of the analgesic activity of the obtained products revealed that compound 5a synthesized from (−)-myrtenal had a higher efficacy compared with the reference drug, diclofenac sodium, in the acetic acid-induced writhing and hot plate tests. Compound 5a exhibits a low acute toxicity and does not cause damage to the gastric mucosa, and its analgesic effect is, at least partially, mediated by the cannabinoid system involving CB1 receptors.
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ГОСТ
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Ponomarev K. et al. Synthesis and analgesic activity of new compounds combining azaadamantane and monoterpene moieties // Medicinal Chemistry Research. 2015. Vol. 24. No. 12. pp. 4146-4156.
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Ponomarev K., Pavlova A., Suslov E., Ardashov O., Korchagina D., Nefedov A., Tolstikova T., Volcho K., Salakhutdinov N. Synthesis and analgesic activity of new compounds combining azaadamantane and monoterpene moieties // Medicinal Chemistry Research. 2015. Vol. 24. No. 12. pp. 4146-4156.
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TY - JOUR
DO - 10.1007/s00044-015-1464-z
UR - https://doi.org/10.1007/s00044-015-1464-z
TI - Synthesis and analgesic activity of new compounds combining azaadamantane and monoterpene moieties
T2 - Medicinal Chemistry Research
AU - Ponomarev, Konstantin
AU - Pavlova, Alla
AU - Suslov, Evgeniy
AU - Ardashov, Oleg
AU - Korchagina, Dina
AU - Nefedov, Andrej
AU - Tolstikova, Tatyana
AU - Volcho, Konstantin
AU - Salakhutdinov, Nariman
PY - 2015
DA - 2015/09/09
PB - Springer Nature
SP - 4146-4156
IS - 12
VL - 24
SN - 1054-2523
SN - 1554-8120
ER -
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@article{2015_Ponomarev,
author = {Konstantin Ponomarev and Alla Pavlova and Evgeniy Suslov and Oleg Ardashov and Dina Korchagina and Andrej Nefedov and Tatyana Tolstikova and Konstantin Volcho and Nariman Salakhutdinov},
title = {Synthesis and analgesic activity of new compounds combining azaadamantane and monoterpene moieties},
journal = {Medicinal Chemistry Research},
year = {2015},
volume = {24},
publisher = {Springer Nature},
month = {sep},
url = {https://doi.org/10.1007/s00044-015-1464-z},
number = {12},
pages = {4146--4156},
doi = {10.1007/s00044-015-1464-z}
}
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MLA
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Ponomarev, Konstantin, et al. “Synthesis and analgesic activity of new compounds combining azaadamantane and monoterpene moieties.” Medicinal Chemistry Research, vol. 24, no. 12, Sep. 2015, pp. 4146-4156. https://doi.org/10.1007/s00044-015-1464-z.
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