Synthesis and analgesic activity of monoterpenoid-derived alkyl-substituted chiral hexahydro-2H-chromenes
Irina Ilina
1, 2
,
Alla Pavlova
1
,
Dina Korchagina
1
,
Oleg Ardashov
1, 2
,
Tatyana Tolstikova
1
,
Konstantin P. Volcho
1, 2
,
Тип публикации: Journal Article
Дата публикации: 2017-03-17
scimago Q2
wos Q3
БС2
SJR: 0.470
CiteScore: 5.1
Impact factor: 3.1
ISSN: 10542523, 15548120
Organic Chemistry
General Pharmacology, Toxicology and Pharmaceutics
Краткое описание
A set of new 2-alkyl-substituted 4,7-dimethyl-3,4,4a,5,8,8a-hexahydro-2H-chromene-4,8-diols was obtained by reactions of monoterpenoid (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol with aliphatic aldehydes in the presence of montmorillonite clay K10. Synthesized compounds were evaluated for their analgesic activity in vivo using the acetic acid-induced writhing test and the hot-plate test. Five compounds showed a significant analgesic activity in the acetic acid-induced writhing test; two of them also demonstrated analgesic activity in the hot-plate test. These compounds seem to be most promising for further development.
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Ilina I. et al. Synthesis and analgesic activity of monoterpenoid-derived alkyl-substituted chiral hexahydro-2H-chromenes // Medicinal Chemistry Research. 2017. Vol. 26. No. 7. pp. 1415-1426.
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Ilina I., Pavlova A., Korchagina D., Ardashov O., Tolstikova T., Volcho K. P., Salakhutdinov N. Synthesis and analgesic activity of monoterpenoid-derived alkyl-substituted chiral hexahydro-2H-chromenes // Medicinal Chemistry Research. 2017. Vol. 26. No. 7. pp. 1415-1426.
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TY - JOUR
DO - 10.1007/s00044-017-1847-4
UR - https://doi.org/10.1007/s00044-017-1847-4
TI - Synthesis and analgesic activity of monoterpenoid-derived alkyl-substituted chiral hexahydro-2H-chromenes
T2 - Medicinal Chemistry Research
AU - Ilina, Irina
AU - Pavlova, Alla
AU - Korchagina, Dina
AU - Ardashov, Oleg
AU - Tolstikova, Tatyana
AU - Volcho, Konstantin P.
AU - Salakhutdinov, Nariman
PY - 2017
DA - 2017/03/17
PB - Springer Nature
SP - 1415-1426
IS - 7
VL - 26
SN - 1054-2523
SN - 1554-8120
ER -
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@article{2017_Ilina,
author = {Irina Ilina and Alla Pavlova and Dina Korchagina and Oleg Ardashov and Tatyana Tolstikova and Konstantin P. Volcho and Nariman Salakhutdinov},
title = {Synthesis and analgesic activity of monoterpenoid-derived alkyl-substituted chiral hexahydro-2H-chromenes},
journal = {Medicinal Chemistry Research},
year = {2017},
volume = {26},
publisher = {Springer Nature},
month = {mar},
url = {https://doi.org/10.1007/s00044-017-1847-4},
number = {7},
pages = {1415--1426},
doi = {10.1007/s00044-017-1847-4}
}
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MLA
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Ilina, Irina, et al. “Synthesis and analgesic activity of monoterpenoid-derived alkyl-substituted chiral hexahydro-2H-chromenes.” Medicinal Chemistry Research, vol. 26, no. 7, Mar. 2017, pp. 1415-1426. https://doi.org/10.1007/s00044-017-1847-4.