Evaluation of cholinesterase inhibitory activity and cytotoxicity of synthetic derivatives of di- and triterpene metabolites from Pinus silvestris and Dipterocarpus alatus resins
Publication type: Journal Article
Publication date: 2020-05-31
scimago Q2
wos Q3
SJR: 0.470
CiteScore: 5.1
Impact factor: 3.1
ISSN: 10542523, 15548120
Organic Chemistry
General Pharmacology, Toxicology and Pharmaceutics
Abstract
A series of hydroxy-, oximino-, lactame, arylidene, N-methylpiperazinyl amide, isoxazole, pyrimidine derivatives of dipterocarpol, quinopimaric, and dammarenolic acids were synthesized and evaluated for cholinesterase inhibitory activity and cytotoxicity. All of the compounds were weak inhibitors for the enzyme acetylcholinesterase while being no inhibitor for butyrylcholinesterase. Dihydroquinopimaric acid was cytotoxic especially for A375 and A2780 tumor cells while being significantly less cytotoxic for nonmalignant fibroblasts (NIH 3T3).
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Smirnova I. et al. Evaluation of cholinesterase inhibitory activity and cytotoxicity of synthetic derivatives of di- and triterpene metabolites from Pinus silvestris and Dipterocarpus alatus resins // Medicinal Chemistry Research. 2020. Vol. 29. No. 8. pp. 1478-1485.
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Smirnova I., Kazakova O. B., Loesche A., Hoenke S., Csuk R. Evaluation of cholinesterase inhibitory activity and cytotoxicity of synthetic derivatives of di- and triterpene metabolites from Pinus silvestris and Dipterocarpus alatus resins // Medicinal Chemistry Research. 2020. Vol. 29. No. 8. pp. 1478-1485.
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RIS
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TY - JOUR
DO - 10.1007/s00044-020-02566-9
UR - https://doi.org/10.1007/s00044-020-02566-9
TI - Evaluation of cholinesterase inhibitory activity and cytotoxicity of synthetic derivatives of di- and triterpene metabolites from Pinus silvestris and Dipterocarpus alatus resins
T2 - Medicinal Chemistry Research
AU - Smirnova, Irina
AU - Kazakova, Oxana B.
AU - Loesche, Anne
AU - Hoenke, Sophie
AU - Csuk, René
PY - 2020
DA - 2020/05/31
PB - Springer Nature
SP - 1478-1485
IS - 8
VL - 29
SN - 1054-2523
SN - 1554-8120
ER -
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BibTex (up to 50 authors)
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@article{2020_Smirnova,
author = {Irina Smirnova and Oxana B. Kazakova and Anne Loesche and Sophie Hoenke and René Csuk},
title = {Evaluation of cholinesterase inhibitory activity and cytotoxicity of synthetic derivatives of di- and triterpene metabolites from Pinus silvestris and Dipterocarpus alatus resins},
journal = {Medicinal Chemistry Research},
year = {2020},
volume = {29},
publisher = {Springer Nature},
month = {may},
url = {https://doi.org/10.1007/s00044-020-02566-9},
number = {8},
pages = {1478--1485},
doi = {10.1007/s00044-020-02566-9}
}
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MLA
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Smirnova, Irina, et al. “Evaluation of cholinesterase inhibitory activity and cytotoxicity of synthetic derivatives of di- and triterpene metabolites from Pinus silvestris and Dipterocarpus alatus resins.” Medicinal Chemistry Research, vol. 29, no. 8, May. 2020, pp. 1478-1485. https://doi.org/10.1007/s00044-020-02566-9.