Analytical and Bioanalytical Chemistry, volume 412, issue 4, pages 811-818
Ultra-low HIV-1 p24 detection limits with a bioelectronic sensor
Eleonora Macchia
1, 2
,
Lucia Sarcina
1
,
Rosaria Anna Picca
1
,
Kyriaki Manoli
1
,
Cinzia Di Franco
1
,
Gaetano Scamarcio
3, 4
,
Luisa Torsi
1, 2, 5
5
CSGI (Centre for Colloid and Surface Science), Bari, Italy
|
Publication type: Journal Article
Publication date: 2019-12-21
Quartile SCImago
Q2
Quartile WOS
Q1
Impact factor: 4.3
ISSN: 16182642, 16182650
Biochemistry
Analytical Chemistry
Abstract
Early diagnosis of the infection caused by human immunodeficiency virus type-1 (HIV-1) is vital to achieve efficient therapeutic treatment and limit the disease spreading when the viremia is at its highest level. To this end, a point-of-care HIV-1 detection carried out with label-free, low-cost, and ultra-sensitive screening technologies would be of great relevance. Herein, a label-free single molecule detection of HIV-1 p24 capsid protein with a large (wide-field) single-molecule transistor (SiMoT) sensor is proposed. The system is based on an electrolyte-gated field-effect transistor whose gate is bio-functionalized with the antibody against the HIV-1 p24 capsid protein. The device exhibits a limit of detection of a single protein and a limit of quantification in the 10 molecule range. This study paves the way for a low-cost technology that can quantify, with single-molecule precision, the transition of a biological organism from being “healthy” to being “diseased” by tracking a target biomarker. This can open to the possibility of performing the earliest possible diagnosis.
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1 publication, 2.22%
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1 publication, 2.22%
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2
4
6
8
10
12
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Macchia E. et al. Ultra-low HIV-1 p24 detection limits with a bioelectronic sensor // Analytical and Bioanalytical Chemistry. 2019. Vol. 412. No. 4. pp. 811-818.
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Macchia E., Sarcina L., Picca R. A., Manoli K., Di Franco C., Scamarcio G., Torsi L. Ultra-low HIV-1 p24 detection limits with a bioelectronic sensor // Analytical and Bioanalytical Chemistry. 2019. Vol. 412. No. 4. pp. 811-818.
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TY - JOUR
DO - 10.1007/s00216-019-02319-7
UR - https://doi.org/10.1007/s00216-019-02319-7
TI - Ultra-low HIV-1 p24 detection limits with a bioelectronic sensor
T2 - Analytical and Bioanalytical Chemistry
AU - Macchia, Eleonora
AU - Sarcina, Lucia
AU - Picca, Rosaria Anna
AU - Manoli, Kyriaki
AU - Di Franco, Cinzia
AU - Scamarcio, Gaetano
AU - Torsi, Luisa
PY - 2019
DA - 2019/12/21 00:00:00
PB - Springer Nature
SP - 811-818
IS - 4
VL - 412
SN - 1618-2642
SN - 1618-2650
ER -
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@article{2019_Macchia,
author = {Eleonora Macchia and Lucia Sarcina and Rosaria Anna Picca and Kyriaki Manoli and Cinzia Di Franco and Gaetano Scamarcio and Luisa Torsi},
title = {Ultra-low HIV-1 p24 detection limits with a bioelectronic sensor},
journal = {Analytical and Bioanalytical Chemistry},
year = {2019},
volume = {412},
publisher = {Springer Nature},
month = {dec},
url = {https://doi.org/10.1007/s00216-019-02319-7},
number = {4},
pages = {811--818},
doi = {10.1007/s00216-019-02319-7}
}
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MLA
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Macchia, Eleonora, et al. “Ultra-low HIV-1 p24 detection limits with a bioelectronic sensor.” Analytical and Bioanalytical Chemistry, vol. 412, no. 4, Dec. 2019, pp. 811-818. https://doi.org/10.1007/s00216-019-02319-7.