Springer Nature
Chromosoma
,  volume 127 ,  issue 4 ,  pages 529-537

Heterochromatin restricts the mobility of nuclear bodies

Eugene A. Arifulin 1
, 
Dmitry V. Sorokin 2
, 
Anna V. Tvorogova 1
, 
Margarita A Kurnaeva 1
, 
Yana R. Musinova 1, 3
, 
Oxana A Zhironkina 1
, 
Sergey A. Golyshev 1
, 
Sergey S. Abramchuk 4
, 
Yegor S. Vassetzky 3, 5, 6
, 
Eugene V. Sheval 1, 5, 7
1
 
2
 
3
 
4
 
5
 
LIA 1066 LFR2O French-Russian Joint Cancer Research Laboratory, Villejuif, France | 
6
 
7
 
Publication type: Journal Article
Publication date: 2018-10-05
Springer Nature
scimago Q2
wos Q3
SJR: 1.013
CiteScore: 4.1
Impact factor: 2.3
ISSN: 00095915, 14320886
Genetics
Genetics(clinical)
Abstract
Nuclear bodies are relatively immobile organelles. Here, we investigated the mechanisms underlying their movement using experimentally induced interphase prenucleolar bodies (iPNBs). Most iPNBs demonstrated constrained diffusion, exhibiting infrequent fusions with other iPNBs and nucleoli. Fusion events were actin-independent and appeared to be the consequence of stochastic collisions between iPNBs. Most iPNBs were surrounded by condensed chromatin, while fusing iPNBs were usually found in a single heterochromatin-delimited compartment (“cage”). The experimentally induced over-condensation of chromatin significantly decreased the frequency of iPNB fusion. Thus, the data obtained indicate that the mobility of nuclear bodies is restricted by heterochromatin.
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Arifulin E. A. et al. Heterochromatin restricts the mobility of nuclear bodies // Chromosoma. 2018. Vol. 127. No. 4. pp. 529-537.
GOST all authors (up to 50) Copy
Arifulin E. A., Sorokin D. V., Tvorogova A. V., Kurnaeva M. A., Musinova Y. R., Zhironkina O. A., Golyshev S., Abramchuk S. S., Vassetzky Y. S., Sheval E. V. Heterochromatin restricts the mobility of nuclear bodies // Chromosoma. 2018. Vol. 127. No. 4. pp. 529-537.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1007/s00412-018-0683-8
UR - https://doi.org/10.1007/s00412-018-0683-8
TI - Heterochromatin restricts the mobility of nuclear bodies
T2 - Chromosoma
AU - Arifulin, Eugene A.
AU - Sorokin, Dmitry V.
AU - Tvorogova, Anna V.
AU - Kurnaeva, Margarita A
AU - Musinova, Yana R.
AU - Zhironkina, Oxana A
AU - Golyshev, Sergey A.
AU - Abramchuk, Sergey S.
AU - Vassetzky, Yegor S.
AU - Sheval, Eugene V.
PY - 2018
DA - 2018/10/05
PB - Springer Nature
SP - 529-537
IS - 4
VL - 127
PMID - 30291421
SN - 0009-5915
SN - 1432-0886
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2018_Arifulin,
author = {Eugene A. Arifulin and Dmitry V. Sorokin and Anna V. Tvorogova and Margarita A Kurnaeva and Yana R. Musinova and Oxana A Zhironkina and Sergey A. Golyshev and Sergey S. Abramchuk and Yegor S. Vassetzky and Eugene V. Sheval},
title = {Heterochromatin restricts the mobility of nuclear bodies},
journal = {Chromosoma},
year = {2018},
volume = {127},
publisher = {Springer Nature},
month = {oct},
url = {https://doi.org/10.1007/s00412-018-0683-8},
number = {4},
pages = {529--537},
doi = {10.1007/s00412-018-0683-8}
}
MLA
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MLA Copy
Arifulin, Eugene A., et al. “Heterochromatin restricts the mobility of nuclear bodies.” Chromosoma, vol. 127, no. 4, Oct. 2018, pp. 529-537. https://doi.org/10.1007/s00412-018-0683-8.