Chromosoma, volume 127, issue 4, pages 529-537
Heterochromatin restricts the mobility of nuclear bodies
Arifulin Eugene A.
1
,
Sorokin Dmitry V.
2
,
Tvorogova Anna V.
1
,
Kurnaeva Margarita A
1
,
Musinova Yana R.
1, 3
,
Abramchuk Sergey S.
4
,
Vassetzky Yegor S.
3, 5, 6
,
Sheval Eugene V.
1, 5, 7
1
5
LIA 1066 LFR2O French-Russian Joint Cancer Research Laboratory, Villejuif, France
|
6
UMR8126, CNRS, Institut de Cancérologie Gustave Roussy, Université Paris-Sud, Villejuif, France
|
Publication type: Journal Article
Publication date: 2018-10-05
Genetics
Genetics(clinical)
Abstract
Nuclear bodies are relatively immobile organelles. Here, we investigated the mechanisms underlying their movement using experimentally induced interphase prenucleolar bodies (iPNBs). Most iPNBs demonstrated constrained diffusion, exhibiting infrequent fusions with other iPNBs and nucleoli. Fusion events were actin-independent and appeared to be the consequence of stochastic collisions between iPNBs. Most iPNBs were surrounded by condensed chromatin, while fusing iPNBs were usually found in a single heterochromatin-delimited compartment (“cage”). The experimentally induced over-condensation of chromatin significantly decreased the frequency of iPNB fusion. Thus, the data obtained indicate that the mobility of nuclear bodies is restricted by heterochromatin.
Citations by journals
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Methods in Molecular Biology
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Methods in Molecular Biology
1 publication, 50%
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Pattern Recognition and Image Analysis
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Pattern Recognition and Image Analysis
1 publication, 50%
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1
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Springer Nature
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Springer Nature
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Pleiades Publishing
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Pleiades Publishing
1 publication, 50%
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1
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Arifulin E. A. et al. Heterochromatin restricts the mobility of nuclear bodies // Chromosoma. 2018. Vol. 127. No. 4. pp. 529-537.
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Arifulin E. A., Sorokin D. V., Tvorogova A. V., Kurnaeva M. A., Musinova Y. R., Zhironkina O. A., Golyshev S., Abramchuk S. S., Vassetzky Y. S., Sheval E. V. Heterochromatin restricts the mobility of nuclear bodies // Chromosoma. 2018. Vol. 127. No. 4. pp. 529-537.
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TY - JOUR
DO - 10.1007/s00412-018-0683-8
UR - https://doi.org/10.1007%2Fs00412-018-0683-8
TI - Heterochromatin restricts the mobility of nuclear bodies
T2 - Chromosoma
AU - Arifulin, Eugene A.
AU - Tvorogova, Anna V.
AU - Kurnaeva, Margarita A
AU - Musinova, Yana R.
AU - Zhironkina, Oxana A
AU - Sorokin, Dmitry V.
AU - Golyshev, Sergey A.
AU - Abramchuk, Sergey S.
AU - Vassetzky, Yegor S.
AU - Sheval, Eugene V.
PY - 2018
DA - 2018/10/05 00:00:00
PB - Springer Nature
SP - 529-537
IS - 4
VL - 127
SN - 0009-5915
SN - 1432-0886
ER -
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@article{2018_Arifulin,
author = {Eugene A. Arifulin and Anna V. Tvorogova and Margarita A Kurnaeva and Yana R. Musinova and Oxana A Zhironkina and Dmitry V. Sorokin and Sergey A. Golyshev and Sergey S. Abramchuk and Yegor S. Vassetzky and Eugene V. Sheval},
title = {Heterochromatin restricts the mobility of nuclear bodies},
journal = {Chromosoma},
year = {2018},
volume = {127},
publisher = {Springer Nature},
month = {oct},
url = {https://doi.org/10.1007%2Fs00412-018-0683-8},
number = {4},
pages = {529--537},
doi = {10.1007/s00412-018-0683-8}
}
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Arifulin, Eugene A., et al. “Heterochromatin restricts the mobility of nuclear bodies.” Chromosoma, vol. 127, no. 4, Oct. 2018, pp. 529-537. https://doi.org/10.1007%2Fs00412-018-0683-8.
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