Metal-free salan-type compound induces apoptosis and overcomes multidrug resistance in leukemic and lymphoma cells in vitro
1
Department of Pediatric Hematology/Oncology, Children’s Hospital Cologne, Cologne, Germany
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Publication type: Journal Article
Publication date: 2018-01-27
scimago Q1
wos Q2
SJR: 0.910
CiteScore: 4.7
Impact factor: 2.8
ISSN: 01715216, 14321335
PubMed ID:
29374786
Cancer Research
Oncology
General Medicine
Abstract
We report on our preclinical findings of a simple salicylic diamine compound (THG 1213) which has yielded exceptional results as a potential chemotherapeutic drug. THG 1213 is an easy to synthesize chiral and metal-free salan compound. THG 1213 was tested on several leukemia, lymphoma and solid tumor cell lines in vitro. The effects have been studied by LDH release essay, FACS flow cytometry, photometric cell count, immunoblotting, and NMR spectroscopy. THG 1213 selectively inhibits proliferation and induces apoptosis in leukemia, lymphoma and solid tumor cell lines. Necrosis or effects on healthy leucocytes could not be detected. Apoptosis is induced via the intrinsic and extrinsic pathways. The salan THG 1213 overcomes multidrug resistance in tumor cells and acts synergistically with vincristine and daunorubicin. THG 1213 displays remarkable antitumor properties. In particular, the lack of metallic components of THG 1213 could prove to be beneficial in future clinical trials, as metal-containing drugs are known to show severe side effects.
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Dragoun M. et al. Metal-free salan-type compound induces apoptosis and overcomes multidrug resistance in leukemic and lymphoma cells in vitro // Journal of Cancer Research and Clinical Oncology. 2018. Vol. 144. No. 4. pp. 685-695.
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Dragoun M., Günther T., Frias C., Berkessel A., Prokop A. Metal-free salan-type compound induces apoptosis and overcomes multidrug resistance in leukemic and lymphoma cells in vitro // Journal of Cancer Research and Clinical Oncology. 2018. Vol. 144. No. 4. pp. 685-695.
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RIS
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TY - JOUR
DO - 10.1007/s00432-018-2592-x
UR - https://doi.org/10.1007/s00432-018-2592-x
TI - Metal-free salan-type compound induces apoptosis and overcomes multidrug resistance in leukemic and lymphoma cells in vitro
T2 - Journal of Cancer Research and Clinical Oncology
AU - Dragoun, Maxim
AU - Günther, Thomas
AU - Frias, Corazon
AU - Berkessel, Albrecht
AU - Prokop, Aram
PY - 2018
DA - 2018/01/27
PB - Springer Nature
SP - 685-695
IS - 4
VL - 144
PMID - 29374786
SN - 0171-5216
SN - 1432-1335
ER -
Cite this
BibTex (up to 50 authors)
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@article{2018_Dragoun,
author = {Maxim Dragoun and Thomas Günther and Corazon Frias and Albrecht Berkessel and Aram Prokop},
title = {Metal-free salan-type compound induces apoptosis and overcomes multidrug resistance in leukemic and lymphoma cells in vitro},
journal = {Journal of Cancer Research and Clinical Oncology},
year = {2018},
volume = {144},
publisher = {Springer Nature},
month = {jan},
url = {https://doi.org/10.1007/s00432-018-2592-x},
number = {4},
pages = {685--695},
doi = {10.1007/s00432-018-2592-x}
}
Cite this
MLA
Copy
Dragoun, Maxim, et al. “Metal-free salan-type compound induces apoptosis and overcomes multidrug resistance in leukemic and lymphoma cells in vitro.” Journal of Cancer Research and Clinical Oncology, vol. 144, no. 4, Jan. 2018, pp. 685-695. https://doi.org/10.1007/s00432-018-2592-x.