Synthesis, structure, and biological activity of novel heterocyclic sulfonyl-carboximidamides
Katarzyna Gobis
1
,
Henryk Foks
1
,
Jarosław Sławiński
1
,
Artur Sikorski
2
,
Damian Trzybiński
2
,
Ewa Augustynowicz-Kopeć
3
,
Agnieszka Napiórkowska
3
,
Krzysztof Bojanowski
4
3
Department of Microbiology, Institute of Tuberculosis and Pulmonary Diseases, Warsaw, Poland
|
4
Sunny BioDiscovery, Santa Paula, USA
|
Publication type: Journal Article
Publication date: 2013-01-25
scimago Q3
wos Q3
SJR: 0.321
CiteScore: 3.4
Impact factor: 1.9
ISSN: 00269247, 14344475
PubMed ID:
26166881
General Chemistry
Abstract
A series of novel heterocyclic sulfonyl-carboximidamides were synthesized in satisfactory yields via condensation of heterocyclic methyl carbimidates with 2-chlorobenzenesulfonamide and 4-chloropyridine-3-sulfonamide. New structures were confirmed by IR and NMR spectra as well as elemental analyses. X-ray crystallography of two derivatives was performed. The single-crystal structures confirmed the presence of a primary amine group in the amidine moiety. All the compounds were screened for their tuberculostatic, antibacterial, and anticancer activities. Preliminary results indicated that target compounds exhibited weak tuberculostatic and antibacterial activities. Seven compounds inhibited the growth of some cancer cell lines, whereas one of the 2-quinoline derivatives displayed favorable activity against all tested cancer cells with GI 50 values of 0.92–13 μM.
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18
Total citations:
18
Citations from 2024:
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(50%)
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GOST
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Gobis K. et al. Synthesis, structure, and biological activity of novel heterocyclic sulfonyl-carboximidamides // Monatshefte fur Chemie. 2013. Vol. 144. No. 5. pp. 647-658.
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Gobis K., Foks H., Sławiński J., Sikorski A., Trzybiński D., Augustynowicz-Kopeć E., Napiórkowska A., Bojanowski K. Synthesis, structure, and biological activity of novel heterocyclic sulfonyl-carboximidamides // Monatshefte fur Chemie. 2013. Vol. 144. No. 5. pp. 647-658.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1007/s00706-012-0888-0
UR - https://doi.org/10.1007/s00706-012-0888-0
TI - Synthesis, structure, and biological activity of novel heterocyclic sulfonyl-carboximidamides
T2 - Monatshefte fur Chemie
AU - Gobis, Katarzyna
AU - Foks, Henryk
AU - Sławiński, Jarosław
AU - Sikorski, Artur
AU - Trzybiński, Damian
AU - Augustynowicz-Kopeć, Ewa
AU - Napiórkowska, Agnieszka
AU - Bojanowski, Krzysztof
PY - 2013
DA - 2013/01/25
PB - Springer Nature
SP - 647-658
IS - 5
VL - 144
PMID - 26166881
SN - 0026-9247
SN - 1434-4475
ER -
Cite this
BibTex (up to 50 authors)
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@article{2013_Gobis,
author = {Katarzyna Gobis and Henryk Foks and Jarosław Sławiński and Artur Sikorski and Damian Trzybiński and Ewa Augustynowicz-Kopeć and Agnieszka Napiórkowska and Krzysztof Bojanowski},
title = {Synthesis, structure, and biological activity of novel heterocyclic sulfonyl-carboximidamides},
journal = {Monatshefte fur Chemie},
year = {2013},
volume = {144},
publisher = {Springer Nature},
month = {jan},
url = {https://doi.org/10.1007/s00706-012-0888-0},
number = {5},
pages = {647--658},
doi = {10.1007/s00706-012-0888-0}
}
Cite this
MLA
Copy
Gobis, Katarzyna, et al. “Synthesis, structure, and biological activity of novel heterocyclic sulfonyl-carboximidamides.” Monatshefte fur Chemie, vol. 144, no. 5, Jan. 2013, pp. 647-658. https://doi.org/10.1007/s00706-012-0888-0.