New Aspects of Biodistribution of Perfluorocarbon Emulsions in Rats: Thymus Imaging

Pavlova O.S., Gulyaev M.V., Anisimov N.V., Silachev D.N., Gervits L.L., Pirogov Y.A.
Тип документаJournal Article
Дата публикации2020-12-01
Название журналаApplied Magnetic Resonance
ИздательSpringer Nature
Квартиль по SCImagoQ4
Квартиль по Web of ScienceQ4
Импакт-фактор 20210.97
ISSN09379347, 16137507
Atomic and Molecular Physics, and Optics
Краткое описание
MRI on fluorine-19 is an effective tool for imaging and monitoring phagocytic cells (macrophages, stem cells, etc.) This method is based on the visualization of perfluorocarbon (PFC) emulsions, which nanoparticles undergo endocytosis by macrophages in an organism. The liver and spleen are main places of emulsion accumulation, but not the only ones. The purpose of our study was to identify organs (besides the liver and spleen) that can accumulate PFC emulsions sufficiently for 19F MRI. We studied the biodistribution of PFC emulsion in rats after two different methods of its introduction into an organism (intravenously and intraperitoneally). It was shown that PFC emulsions are accumulated by the thymus and the nearest lymph nodes in the sufficient amount (around 2% of the total intraperitoneally injected dose) to be visualized. It turned out that PFC emulsion is accumulated more in thymus after intraperitoneal injection in comparison with intravenous injection. This is due to the differences in the capture of emulsion by macrophages when it is initially injected into the bloodstream or the abdomen.
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1. Pavlova O.S. и др. New Aspects of Biodistribution of Perfluorocarbon Emulsions in Rats: Thymus Imaging // Applied Magnetic Resonance. 2020. Т. 51. № 12. С. 1625–1635.
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TY - JOUR

DO - 10.1007/s00723-020-01242-w

UR - http://dx.doi.org/10.1007/s00723-020-01242-w

TI - New Aspects of Biodistribution of Perfluorocarbon Emulsions in Rats: Thymus Imaging

T2 - Applied Magnetic Resonance

AU - Pavlova, Olga S.

AU - Gulyaev, Mikhail V.

AU - Anisimov, Nikolay V.

AU - Silachev, Denis N.

AU - Gervits, Lev L.

AU - Pirogov, Yury A.

PY - 2020

DA - 2020/08/28

PB - Springer Science and Business Media LLC

SP - 1625-1635

IS - 12

VL - 51

SN - 0937-9347

SN - 1613-7507

ER -

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@article{2020,

doi = {10.1007/s00723-020-01242-w},

url = {https://doi.org/10.1007%2Fs00723-020-01242-w},

year = 2020,

month = {aug},

publisher = {Springer Science and Business Media {LLC}},

volume = {51},

number = {12},

pages = {1625--1635},

author = {Olga S. Pavlova and Mikhail V. Gulyaev and Nikolay V. Anisimov and Denis N. Silachev and Lev L. Gervits and Yury A. Pirogov},

title = {New Aspects of Biodistribution of Perfluorocarbon Emulsions in Rats: Thymus Imaging}

}

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Pavlova, Olga S. et al. “New Aspects of Biodistribution of Perfluorocarbon Emulsions in Rats: Thymus Imaging.” Applied Magnetic Resonance 51.12 (2020): 1625–1635. Crossref. Web.