Open Access
Journal of Orthopaedics and Traumatology, volume 17, issue 4, pages 369-376
Failure of the first step of two-stage revision due to polymicrobial prosthetic joint infection of the hip
Publication type: Journal Article
Publication date: 2016-07-07
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 2.8
ISSN: 15909921, 15909999
PubMed ID:
27387172
Surgery
Orthopedics and Sports Medicine
Abstract
The unsuccessful treatment of prosthetic joint infection (PJI) with two-stage revision leads to infection recurrence. The objectives of the study were to assess the clinical and demographic characteristics of patients with polymicrobial PJI, and to evaluate the role of the microbial profile involved in PJI in the risk of infection recurrence after the first step of two-stage revision surgery. A retrospective analysis of 189 cases of culture-positive PJI following total hip replacement over a 5-year period was performed. The demographic characteristics of patients, clinical symptoms, microbiology cultures of intraoperative biopsies, laboratory values of C-reactive protein (CRP), white blood cell count and erythrocyte sedimentation rate were analyzed. Patients were divided into two groups—135 with monomicrobial and 54 with polymicrobial infection. Of all patients, 68.9 % in the monomicrobial and 83.3 % in the polymicrobial group had a body mass index >25 kg/m2 (p = 0.05). The median CRP values were 5.7 mg/L (IQR 4.0–10.0 mg/L) in the monomicrobial compared to 8.8 mg/L (IQR 5.0–27 mg/L) in the polymicrobial group (p = 0.01). The percentage of successful outcomes was 27.8 % in patients with microbial associations (p < 0.0001). Gram-negative pathogens caused polymicrobial PJI in 61.5 % of cases with infection recurrence (OR 4.4; 95 % CI 1.18–16.37; p = 0.03). Overweight and obese patients or those with elevated CRP had a greater risk of polymicrobial PJI. They were predisposed to recurrence of infection after the first step of two-stage revision. An unsuccessful outcome was more likely in cases with polymicrobial infection compared to those with monomicrobial infection. In addition, the presence of multidrug-resistant strains of Gram-negative bacteria substantially increased the risk of PJI treatment being unsuccessful. Level III, therapeutic study.
Top-30
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Citations by publishers
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Springer Nature
7 publications, 29.17%
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Hindawi Limited
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Media Sphere Publishing Group
1 publication, 4.17%
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1 publication, 4.17%
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1 publication, 4.17%
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Paediatrician Publishers LLC
1 publication, 4.17%
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Eco-Vector LLC
1 publication, 4.17%
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Bozhkova S. et al. Failure of the first step of two-stage revision due to polymicrobial prosthetic joint infection of the hip // Journal of Orthopaedics and Traumatology. 2016. Vol. 17. No. 4. pp. 369-376.
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Bozhkova S., Tikhilov R., Labutin D., Denisov A., Shubnyakov I., Razorenov V., Artyukh V., Rukina A. Failure of the first step of two-stage revision due to polymicrobial prosthetic joint infection of the hip // Journal of Orthopaedics and Traumatology. 2016. Vol. 17. No. 4. pp. 369-376.
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TY - JOUR
DO - 10.1007/s10195-016-0417-8
UR - https://doi.org/10.1007/s10195-016-0417-8
TI - Failure of the first step of two-stage revision due to polymicrobial prosthetic joint infection of the hip
T2 - Journal of Orthopaedics and Traumatology
AU - Bozhkova, Svetlana
AU - Tikhilov, Rashid
AU - Labutin, Dmitry
AU - Denisov, Alexey
AU - Shubnyakov, Igor
AU - Razorenov, Vadim
AU - Artyukh, Vasilii
AU - Rukina, Anna
PY - 2016
DA - 2016/07/07 00:00:00
PB - Springer Nature
SP - 369-376
IS - 4
VL - 17
PMID - 27387172
SN - 1590-9921
SN - 1590-9999
ER -
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@article{2016_Bozhkova,
author = {Svetlana Bozhkova and Rashid Tikhilov and Dmitry Labutin and Alexey Denisov and Igor Shubnyakov and Vadim Razorenov and Vasilii Artyukh and Anna Rukina},
title = {Failure of the first step of two-stage revision due to polymicrobial prosthetic joint infection of the hip},
journal = {Journal of Orthopaedics and Traumatology},
year = {2016},
volume = {17},
publisher = {Springer Nature},
month = {jul},
url = {https://doi.org/10.1007/s10195-016-0417-8},
number = {4},
pages = {369--376},
doi = {10.1007/s10195-016-0417-8}
}
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MLA
Copy
Bozhkova, Svetlana, et al. “Failure of the first step of two-stage revision due to polymicrobial prosthetic joint infection of the hip.” Journal of Orthopaedics and Traumatology, vol. 17, no. 4, Jul. 2016, pp. 369-376. https://doi.org/10.1007/s10195-016-0417-8.