A Study of the Cytotoxic Effect of Microcapsules and Their Constituent Polymers on Macrophages and Tumor Cells
Publication type: Journal Article
Publication date: 2018-11-18
scimago Q3
wos Q4
SJR: 0.277
CiteScore: 1.5
Impact factor: 0.6
ISSN: 00074888, 15738221, 03659615, 24131008
PubMed ID:
30450523
General Biochemistry, Genetics and Molecular Biology
General Medicine
Abstract
We studied the effect of different concentrations of polyelectrolytes poly(allylamine hydrochloride) (PAH) and polystyrene sulfonate (PSS) as well as the effects of microcapsules coated with these polymers on survival of Ehrlich ascites carcinoma cells and mouse peritoneal macrophages and on ROS production by phagocytes. PAH reduced viability of Ehrlich ascites carcinoma in a concentration-dependent manner (LD50=12-15 μg/ml). This effect was presumably determined by its ability to bind phosphates, thereby depleting the culture medium. At the same time, PAH did not affect the viability of macrophages. PSS produced no cytotoxic effect on the examined cells. Polyelectrolyte capsules with the shell architectonics (PAH/PSS)3 and (PAH/PSS)3PAH in the examined concentration range had no effect on the viability of macrophages and tumor cells. PAH microcapsules with positively charged surface much more rapidly and more intensively activated macrophages. The chemiluminescence response directly depended on the amount of capsules in the solution.
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Naumov A. A. et al. A Study of the Cytotoxic Effect of Microcapsules and Their Constituent Polymers on Macrophages and Tumor Cells // Bulletin of Experimental Biology and Medicine. 2018. Vol. 166. No. 1. pp. 69-74.
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Naumov A. A., Dubrovskii A. V., Musin E. V., Kim A. L., Potselueva M. M., Tikhonenko S. A. A Study of the Cytotoxic Effect of Microcapsules and Their Constituent Polymers on Macrophages and Tumor Cells // Bulletin of Experimental Biology and Medicine. 2018. Vol. 166. No. 1. pp. 69-74.
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TY - JOUR
DO - 10.1007/s10517-018-4291-7
UR - http://link.springer.com/10.1007/s10517-018-4291-7
TI - A Study of the Cytotoxic Effect of Microcapsules and Their Constituent Polymers on Macrophages and Tumor Cells
T2 - Bulletin of Experimental Biology and Medicine
AU - Naumov, A A
AU - Dubrovskii, A V
AU - Musin, E. V.
AU - Kim, A. L.
AU - Potselueva, M M
AU - Tikhonenko, S. A.
PY - 2018
DA - 2018/11/18
PB - Springer Nature
SP - 69-74
IS - 1
VL - 166
PMID - 30450523
SN - 0007-4888
SN - 1573-8221
SN - 0365-9615
SN - 2413-1008
ER -
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@article{2018_Naumov,
author = {A A Naumov and A V Dubrovskii and E. V. Musin and A. L. Kim and M M Potselueva and S. A. Tikhonenko},
title = {A Study of the Cytotoxic Effect of Microcapsules and Their Constituent Polymers on Macrophages and Tumor Cells},
journal = {Bulletin of Experimental Biology and Medicine},
year = {2018},
volume = {166},
publisher = {Springer Nature},
month = {nov},
url = {http://link.springer.com/10.1007/s10517-018-4291-7},
number = {1},
pages = {69--74},
doi = {10.1007/s10517-018-4291-7}
}
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MLA
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Naumov, A. A., et al. “A Study of the Cytotoxic Effect of Microcapsules and Their Constituent Polymers on Macrophages and Tumor Cells.” Bulletin of Experimental Biology and Medicine, vol. 166, no. 1, Nov. 2018, pp. 69-74. http://link.springer.com/10.1007/s10517-018-4291-7.