Influence of Tumor Suppressor p53 Functioning on the Expression of Antioxidant System Genes under the Action of Cytotoxic Compounds
V A Mumyatova
1, 2
,
A A Balakina
1, 2
,
M A Lapshina
1, 2
,
V D Sen
1
,
A B Kornev
1
,
A A Terentev
1, 2, 3
Publication type: Journal Article
Publication date: 2020-05-01
scimago Q3
wos Q4
SJR: 0.277
CiteScore: 1.5
Impact factor: 0.6
ISSN: 00074888, 15738221, 03659615, 24131008
PubMed ID:
32504383
General Biochemistry, Genetics and Molecular Biology
General Medicine
Abstract
The effect of inhibition of the tumor suppressor p53 on the antioxidant system genes expression under the influence of cytotoxic compounds of the platinum group was studied. It was found that the action of platinum(II) and platinum(IV) complexes induced accumulation of p53 protein with a maximum in 12 h, which was confirmed by an increase in the expression of the P21 gene, the target gene of the p53 protein. It was shown that the action of platinum complexes activated the expression of catalase and superoxide dismutase 2 genes. Suppression of p53 protein functions with specific inhibitor α-piphitrin under the action of platinum complexes reduced the expression of catalase and superoxide dismutase 2 genes and the target gene P21, which attested to the p53-dependent regulation of these genes.
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Mumyatova V. A. et al. Influence of Tumor Suppressor p53 Functioning on the Expression of Antioxidant System Genes under the Action of Cytotoxic Compounds // Bulletin of Experimental Biology and Medicine. 2020. Vol. 169. No. 1. pp. 169-175.
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Mumyatova V. A., Balakina A. A., Lapshina M. A., Sen V. D., Kornev A. B., Terentev A. A. Influence of Tumor Suppressor p53 Functioning on the Expression of Antioxidant System Genes under the Action of Cytotoxic Compounds // Bulletin of Experimental Biology and Medicine. 2020. Vol. 169. No. 1. pp. 169-175.
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TY - JOUR
DO - 10.1007/s10517-020-04844-3
UR - https://doi.org/10.1007/s10517-020-04844-3
TI - Influence of Tumor Suppressor p53 Functioning on the Expression of Antioxidant System Genes under the Action of Cytotoxic Compounds
T2 - Bulletin of Experimental Biology and Medicine
AU - Mumyatova, V A
AU - Balakina, A A
AU - Lapshina, M A
AU - Sen, V D
AU - Kornev, A B
AU - Terentev, A A
PY - 2020
DA - 2020/05/01
PB - Springer Nature
SP - 169-175
IS - 1
VL - 169
PMID - 32504383
SN - 0007-4888
SN - 1573-8221
SN - 0365-9615
SN - 2413-1008
ER -
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@article{2020_Mumyatova,
author = {V A Mumyatova and A A Balakina and M A Lapshina and V D Sen and A B Kornev and A A Terentev},
title = {Influence of Tumor Suppressor p53 Functioning on the Expression of Antioxidant System Genes under the Action of Cytotoxic Compounds},
journal = {Bulletin of Experimental Biology and Medicine},
year = {2020},
volume = {169},
publisher = {Springer Nature},
month = {may},
url = {https://doi.org/10.1007/s10517-020-04844-3},
number = {1},
pages = {169--175},
doi = {10.1007/s10517-020-04844-3}
}
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Mumyatova, V. A., et al. “Influence of Tumor Suppressor p53 Functioning on the Expression of Antioxidant System Genes under the Action of Cytotoxic Compounds.” Bulletin of Experimental Biology and Medicine, vol. 169, no. 1, May. 2020, pp. 169-175. https://doi.org/10.1007/s10517-020-04844-3.
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