Cytostatic Activity of Combretastatin A-4 Derivatives in an In Vitro System
A D Plyutinskaya
1
,
E. R. Nemtsova
1
,
A. A. Pankratov
1
,
P V Shegai
1
,
S S Krylov
2
,
V N Iskandarova
3
,
A S Maksimenko
2
,
D V Demchuk
2
,
T S Kuptsova
2
,
M. N. Semenova
4
,
V. V. Semenov
2
1
National Medical Research Center of Radiology, Ministry of Health of the Russian Federation, Moscow, Russia
|
3
LLC “Skandiya”, Moscow, Russia
|
Publication type: Journal Article
Publication date: 2022-12-01
scimago Q3
wos Q4
SJR: 0.277
CiteScore: 1.5
Impact factor: 0.6
ISSN: 00074888, 15738221, 03659615, 24131008
PubMed ID:
36600040
General Biochemistry, Genetics and Molecular Biology
General Medicine
Abstract
Cytostatic activity of combretastatin A-4, its 11 analogues, and paclitaxel (Taxacad) was evaluated in vitro on human tumor cells A549 (lung adenocarcinoma) and PC-3 (prostate adenocarcinoma) in order to find the active and stable compound as a promising antitumor agent. 5-(4-Methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-isoxazole (compound 123124) and 3-(3,4,5-trimethoxyphenyl)-4-(4-methoxyphenyl)-isoxazole (compound 29310186) demonstrated the highest cytostatic activity (IC50≈8×10—9 М). The activity of two other cytotoxic compounds (2E)-1-(7-methoxy-2H-1,3-benzodioxol-5-yl)-3-(4-methoxyphenyl)prop-2-en-1-one (compound 104815) and 4-(3-amino-4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-pyrazole hydrochloride (compound 198732) was close to that of Taxacad: IC50 65×10—9 and 80×10—9 М, respectively, and are also promising active components for the development of antitumor drugs.
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Plyutinskaya A. D. et al. Cytostatic Activity of Combretastatin A-4 Derivatives in an In Vitro System // Bulletin of Experimental Biology and Medicine. 2022. Vol. 174. No. 2. pp. 221-225.
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Plyutinskaya A. D., Nemtsova E. R., Pankratov A. A., Shegai P. V., Krylov S. S., Iskandarova V. N., Maksimenko A. S., Demchuk D. V., Kuptsova T. S., Semenova M. N., Semenov V. V. Cytostatic Activity of Combretastatin A-4 Derivatives in an In Vitro System // Bulletin of Experimental Biology and Medicine. 2022. Vol. 174. No. 2. pp. 221-225.
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TY - JOUR
DO - 10.1007/s10517-023-05677-6
UR - https://doi.org/10.1007/s10517-023-05677-6
TI - Cytostatic Activity of Combretastatin A-4 Derivatives in an In Vitro System
T2 - Bulletin of Experimental Biology and Medicine
AU - Plyutinskaya, A D
AU - Nemtsova, E. R.
AU - Pankratov, A. A.
AU - Shegai, P V
AU - Krylov, S S
AU - Iskandarova, V N
AU - Maksimenko, A S
AU - Demchuk, D V
AU - Kuptsova, T S
AU - Semenova, M. N.
AU - Semenov, V. V.
PY - 2022
DA - 2022/12/01
PB - Springer Nature
SP - 221-225
IS - 2
VL - 174
PMID - 36600040
SN - 0007-4888
SN - 1573-8221
SN - 0365-9615
SN - 2413-1008
ER -
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BibTex (up to 50 authors)
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@article{2022_Plyutinskaya,
author = {A D Plyutinskaya and E. R. Nemtsova and A. A. Pankratov and P V Shegai and S S Krylov and V N Iskandarova and A S Maksimenko and D V Demchuk and T S Kuptsova and M. N. Semenova and V. V. Semenov},
title = {Cytostatic Activity of Combretastatin A-4 Derivatives in an In Vitro System},
journal = {Bulletin of Experimental Biology and Medicine},
year = {2022},
volume = {174},
publisher = {Springer Nature},
month = {dec},
url = {https://doi.org/10.1007/s10517-023-05677-6},
number = {2},
pages = {221--225},
doi = {10.1007/s10517-023-05677-6}
}
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MLA
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Plyutinskaya, A. D., et al. “Cytostatic Activity of Combretastatin A-4 Derivatives in an In Vitro System.” Bulletin of Experimental Biology and Medicine, vol. 174, no. 2, Dec. 2022, pp. 221-225. https://doi.org/10.1007/s10517-023-05677-6.