Biological and physicochemical evaluation of the conformational stability of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
Publication type: Journal Article
Publication date: 2007-02-23
scimago Q2
wos Q3
SJR: 0.528
CiteScore: 5.4
Impact factor: 2.1
ISSN: 01415492, 15736776
PubMed ID:
17318333
General Medicine
Applied Microbiology and Biotechnology
Biotechnology
Bioengineering
Abstract
Tumor necrosis factor (TNF)-related, apoptosis-inducing ligand (Apo2L/TRAIL) has a unique homotrimeric structure, and its conformational stability is essential for its apoptotic activity. The conformational stability of a modified version of TRAIL(114–281) with two additional domains of histidine tag and isoleucine zipper [His-ILZ-TRAIL(114–281)] was evaluated in various pH environments according to three different biological or physicochemical considerations: cytotoxicity, antibody-binding affinity, and tertiary structure. The biological properties of His-ILZ-TRAIL(114–281) were the most stably maintained at pH 6.0. The physicochemical analyses (circular dichroism and fluorescence spectroscopy) demonstrate that its bioactivity loss by pH challenge was originated from its structural collapse as a homotrimer.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
4
|
|
|
Biomaterials
4 publications, 18.18%
|
|
|
Journal of Controlled Release
2 publications, 9.09%
|
|
|
Journal of Pharmacology and Experimental Therapeutics
1 publication, 4.55%
|
|
|
Oncology Letters
1 publication, 4.55%
|
|
|
Archives of Pharmacal Research
1 publication, 4.55%
|
|
|
Cell Death and Differentiation
1 publication, 4.55%
|
|
|
Biotechnology Letters
1 publication, 4.55%
|
|
|
Journal of Pharmaceutical Sciences
1 publication, 4.55%
|
|
|
International Journal of Pharmaceutics
1 publication, 4.55%
|
|
|
Acta Biomaterialia
1 publication, 4.55%
|
|
|
Biomedicine and Pharmacotherapy
1 publication, 4.55%
|
|
|
European Journal of Pharmacology
1 publication, 4.55%
|
|
|
Molecular Crystals and Liquid Crystals
1 publication, 4.55%
|
|
|
Journal of Biomaterials Science, Polymer Edition
1 publication, 4.55%
|
|
|
Molecular Cancer Therapeutics
1 publication, 4.55%
|
|
|
Cell Death and Disease
1 publication, 4.55%
|
|
|
Russian Chemical Reviews
1 publication, 4.55%
|
|
|
1
2
3
4
|
Publishers
|
2
4
6
8
10
12
|
|
|
Elsevier
11 publications, 50%
|
|
|
Springer Nature
3 publications, 13.64%
|
|
|
Taylor & Francis
2 publications, 9.09%
|
|
|
American Society for Pharmacology and Experimental Therapeutics
1 publication, 4.55%
|
|
|
Spandidos Publications
1 publication, 4.55%
|
|
|
Pharmaceutical Society of Korea
1 publication, 4.55%
|
|
|
American Association for Cancer Research (AACR)
1 publication, 4.55%
|
|
|
Cold Spring Harbor Laboratory
1 publication, 4.55%
|
|
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 4.55%
|
|
|
2
4
6
8
10
12
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
22
Total citations:
22
Citations from 2024:
2
(9.1%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Youn Yu. S. et al. Biological and physicochemical evaluation of the conformational stability of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) // Biotechnology Letters. 2007. Vol. 29. No. 5. pp. 713-721.
GOST all authors (up to 50)
Copy
Youn Yu. S., Shin M. J., Chae S. Y., Jin C., Kim T. H., Lee K. C. Biological and physicochemical evaluation of the conformational stability of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) // Biotechnology Letters. 2007. Vol. 29. No. 5. pp. 713-721.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1007/s10529-006-9300-7
UR - https://doi.org/10.1007/s10529-006-9300-7
TI - Biological and physicochemical evaluation of the conformational stability of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
T2 - Biotechnology Letters
AU - Youn, Yu Seok
AU - Shin, Min Jae
AU - Chae, Su Young
AU - Jin, Cheng-Hao
AU - Kim, Tae Hyung
AU - Lee, Kang Choon
PY - 2007
DA - 2007/02/23
PB - Springer Nature
SP - 713-721
IS - 5
VL - 29
PMID - 17318333
SN - 0141-5492
SN - 1573-6776
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2007_Youn,
author = {Yu Seok Youn and Min Jae Shin and Su Young Chae and Cheng-Hao Jin and Tae Hyung Kim and Kang Choon Lee},
title = {Biological and physicochemical evaluation of the conformational stability of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)},
journal = {Biotechnology Letters},
year = {2007},
volume = {29},
publisher = {Springer Nature},
month = {feb},
url = {https://doi.org/10.1007/s10529-006-9300-7},
number = {5},
pages = {713--721},
doi = {10.1007/s10529-006-9300-7}
}
Cite this
MLA
Copy
Youn, Yu. Seok, et al. “Biological and physicochemical evaluation of the conformational stability of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).” Biotechnology Letters, vol. 29, no. 5, Feb. 2007, pp. 713-721. https://doi.org/10.1007/s10529-006-9300-7.