Biological and physicochemical evaluation of the conformational stability of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
Тип публикации: Journal Article
Дата публикации: 2007-02-23
scimago Q2
wos Q3
БС2
SJR: 0.528
CiteScore: 5.4
Impact factor: 2.1
ISSN: 01415492, 15736776
PubMed ID:
17318333
General Medicine
Applied Microbiology and Biotechnology
Biotechnology
Bioengineering
Краткое описание
Tumor necrosis factor (TNF)-related, apoptosis-inducing ligand (Apo2L/TRAIL) has a unique homotrimeric structure, and its conformational stability is essential for its apoptotic activity. The conformational stability of a modified version of TRAIL(114–281) with two additional domains of histidine tag and isoleucine zipper [His-ILZ-TRAIL(114–281)] was evaluated in various pH environments according to three different biological or physicochemical considerations: cytotoxicity, antibody-binding affinity, and tertiary structure. The biological properties of His-ILZ-TRAIL(114–281) were the most stably maintained at pH 6.0. The physicochemical analyses (circular dichroism and fluorescence spectroscopy) demonstrate that its bioactivity loss by pH challenge was originated from its structural collapse as a homotrimer.
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ГОСТ
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Youn Yu. S. et al. Biological and physicochemical evaluation of the conformational stability of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) // Biotechnology Letters. 2007. Vol. 29. No. 5. pp. 713-721.
ГОСТ со всеми авторами (до 50)
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Youn Yu. S., Shin M. J., Chae S. Y., Jin C., Kim T. H., Lee K. C. Biological and physicochemical evaluation of the conformational stability of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) // Biotechnology Letters. 2007. Vol. 29. No. 5. pp. 713-721.
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TY - JOUR
DO - 10.1007/s10529-006-9300-7
UR - https://doi.org/10.1007/s10529-006-9300-7
TI - Biological and physicochemical evaluation of the conformational stability of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
T2 - Biotechnology Letters
AU - Youn, Yu Seok
AU - Shin, Min Jae
AU - Chae, Su Young
AU - Jin, Cheng-Hao
AU - Kim, Tae Hyung
AU - Lee, Kang Choon
PY - 2007
DA - 2007/02/23
PB - Springer Nature
SP - 713-721
IS - 5
VL - 29
PMID - 17318333
SN - 0141-5492
SN - 1573-6776
ER -
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BibTex (до 50 авторов)
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@article{2007_Youn,
author = {Yu Seok Youn and Min Jae Shin and Su Young Chae and Cheng-Hao Jin and Tae Hyung Kim and Kang Choon Lee},
title = {Biological and physicochemical evaluation of the conformational stability of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)},
journal = {Biotechnology Letters},
year = {2007},
volume = {29},
publisher = {Springer Nature},
month = {feb},
url = {https://doi.org/10.1007/s10529-006-9300-7},
number = {5},
pages = {713--721},
doi = {10.1007/s10529-006-9300-7}
}
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MLA
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Youn, Yu. Seok, et al. “Biological and physicochemical evaluation of the conformational stability of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).” Biotechnology Letters, vol. 29, no. 5, Feb. 2007, pp. 713-721. https://doi.org/10.1007/s10529-006-9300-7.