Hairy root biotechnology of Rauwolfia serpentina: a potent approach for the production of pharmaceutically important terpenoid indole alkaloids
Publication type: Journal Article
Publication date: 2014-10-18
scimago Q2
wos Q3
SJR: 0.528
CiteScore: 5.4
Impact factor: 2.1
ISSN: 01415492, 15736776
PubMed ID:
25326172
General Medicine
Applied Microbiology and Biotechnology
Biotechnology
Bioengineering
Abstract
Hairy root cultures of Rauwolfia serpentina induced by Agrobacterium rhizogenes have been investigated extensively for the production of terpenoid indole alkaloids. Various biotechnological developments, such as scaling up in bioreactors, pathway engineering etc., have been explored to improve their metabolite production potential. These hairy roots are competent for regenerating into complete plants and show survival and unaltered biosynthetic potential during storage at low temperature. This review provides a comprehensive account of the hairy root cultures of R. serpentina, their biosynthetic potential and various biotechnological methods used to explore the production of pharmaceutically important terpenoid indole alkaloids. The review also indicates how biotechnological endeavors might improve the future progress of research for production of alkaloids using Rauwolfia hairy roots.
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55
Total citations:
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Citations from 2025:
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(7.27%)
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MLA
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GOST
Copy
Mehrotra S. et al. Hairy root biotechnology of Rauwolfia serpentina: a potent approach for the production of pharmaceutically important terpenoid indole alkaloids // Biotechnology Letters. 2014. Vol. 37. No. 2. pp. 253-263.
GOST all authors (up to 50)
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Mehrotra S., Goel M. K., Srivastava V., Rahman L. U. Hairy root biotechnology of Rauwolfia serpentina: a potent approach for the production of pharmaceutically important terpenoid indole alkaloids // Biotechnology Letters. 2014. Vol. 37. No. 2. pp. 253-263.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1007/s10529-014-1695-y
UR - https://doi.org/10.1007/s10529-014-1695-y
TI - Hairy root biotechnology of Rauwolfia serpentina: a potent approach for the production of pharmaceutically important terpenoid indole alkaloids
T2 - Biotechnology Letters
AU - Mehrotra, Shakti
AU - Goel, Manoj K.
AU - Srivastava, Vikas
AU - Rahman, Laiq ur
PY - 2014
DA - 2014/10/18
PB - Springer Nature
SP - 253-263
IS - 2
VL - 37
PMID - 25326172
SN - 0141-5492
SN - 1573-6776
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2014_Mehrotra,
author = {Shakti Mehrotra and Manoj K. Goel and Vikas Srivastava and Laiq ur Rahman},
title = {Hairy root biotechnology of Rauwolfia serpentina: a potent approach for the production of pharmaceutically important terpenoid indole alkaloids},
journal = {Biotechnology Letters},
year = {2014},
volume = {37},
publisher = {Springer Nature},
month = {oct},
url = {https://doi.org/10.1007/s10529-014-1695-y},
number = {2},
pages = {253--263},
doi = {10.1007/s10529-014-1695-y}
}
Cite this
MLA
Copy
Mehrotra, Shakti, et al. “Hairy root biotechnology of Rauwolfia serpentina: a potent approach for the production of pharmaceutically important terpenoid indole alkaloids.” Biotechnology Letters, vol. 37, no. 2, Oct. 2014, pp. 253-263. https://doi.org/10.1007/s10529-014-1695-y.