Springer Nature
Chemistry of Heterocyclic Compounds
,  том 41 ,  издание 5 ,  страницы 625-629

Synthesis and Antiviral Activity of 1-{[2-(Phenoxy)ethoxy]methyl}uracil Derivatives

Тип публикации: Journal Article
Дата публикации: 2005-05-01
Springer Nature
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CiteScore: 2.7
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ISSN: 00093122, 15738353
Organic Chemistry
Краткое описание
The synthesis of novel 1-{[2-(phenoxy)ethoxy]methyl}uracil derivatives with different substituents in positions and 6 of the pyrimidine ring has been carried out. It has been shown that the alkylation of trimethylsilyl derivatives of uracil with 2-(4-chlorophenoxy)- and 2-(4-methylphenoxy)ethoxymethyl chloride under Hilbert-Johnson reaction conditions gives N(1)-substitution products. It was found that the 1-{ [2-(phenoxy)ethoxy]methyl}uracil derivatives show viral inhibition properties relative to human immunodeficiency type 1 virus in vitro. The most active compounds are 5-bromo-6-methyluracil derivatives which suppress viral reproduction by 50% at 7.2 and 7.8 micromolar concentrations.
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Novikov M. et al. Synthesis and Antiviral Activity of 1-{[2-(Phenoxy)ethoxy]methyl}uracil Derivatives // Chemistry of Heterocyclic Compounds. 2005. Vol. 41. No. 5. pp. 625-629.
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Novikov M., Ozerov A., Orlova Yu. A., Buckheit R. W. Synthesis and Antiviral Activity of 1-{[2-(Phenoxy)ethoxy]methyl}uracil Derivatives // Chemistry of Heterocyclic Compounds. 2005. Vol. 41. No. 5. pp. 625-629.
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TY - JOUR
DO - 10.1007/s10593-005-0193-5
UR - https://doi.org/10.1007/s10593-005-0193-5
TI - Synthesis and Antiviral Activity of 1-{[2-(Phenoxy)ethoxy]methyl}uracil Derivatives
T2 - Chemistry of Heterocyclic Compounds
AU - Novikov, M.S.
AU - Ozerov, A.A.
AU - Orlova, Yu A
AU - Buckheit, R W
PY - 2005
DA - 2005/05/01
PB - Springer Nature
SP - 625-629
IS - 5
VL - 41
SN - 0009-3122
SN - 1573-8353
ER -
BibTex |
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@article{2005_Novikov,
author = {M.S. Novikov and A.A. Ozerov and Yu A Orlova and R W Buckheit},
title = {Synthesis and Antiviral Activity of 1-{[2-(Phenoxy)ethoxy]methyl}uracil Derivatives},
journal = {Chemistry of Heterocyclic Compounds},
year = {2005},
volume = {41},
publisher = {Springer Nature},
month = {may},
url = {https://doi.org/10.1007/s10593-005-0193-5},
number = {5},
pages = {625--629},
doi = {10.1007/s10593-005-0193-5}
}
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Novikov, M.S., et al. “Synthesis and Antiviral Activity of 1-{[2-(Phenoxy)ethoxy]methyl}uracil Derivatives.” Chemistry of Heterocyclic Compounds, vol. 41, no. 5, May. 2005, pp. 625-629. https://doi.org/10.1007/s10593-005-0193-5.