Chemistry of Heterocyclic Compounds

, том 52 , издание 3 , страницы 155-157

Synthesis of [1,2,4]triazolo[1,5-a]pyrimidine (microreview)

Тип публикации: Journal Article

Дата публикации: 2016-03-01

Springer Nature

Chemistry of Heterocyclic Compounds

scimago Q4

wos Q4

БС3

SJR: 0.243

CiteScore: 2.7

Impact factor: 1

ISSN: 00093122, 15738353

DOI: 10.1007/s10593-016-1851-5

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Organic Chemistry

Краткое описание

[1,2,4]Triazolo[1,5-a]pyrimidines are very interesting and trend class of fused heterocycles due to their valuable biological properties. Some [1,2,4]-triazolo[1,5-a]pyrimidines possess herbicidal activity,1 also they can act as antifungal,2 antitubercular,3 and antibacterial4 agents. Polycyclic systems containing [1,2,4]triazolo[1,5-a]-pyrimidine moiety are reported as antitumor,5 as corticotropin-releasing factor 1 receptor antagonists6 or calcium channel modulators;7 they can be used for treatment of Alzheimer's disease8 and insomnia.9 Complexes of triazolo-pyrimidines with Pt and Ru are highly active against parasites10 and can also be used in treating cancer.11 The synthetic ways for the preparation of [1,2,4]triazolo[1,5-a]-pyrimidines can be divided into two main groups: annulation of pyrimidine moiety to triazole ring and annulation of triazole fragment to pyrimidine ring. The Dimroth rearrangement of [1,2,4]triazolo[4,3-a]pyrimidines can also be used for the synthesis of [1,2,4]triazolo[1,5-a]pyrimidines. In this review article we have focused on synthetic approaches for the creation of [1,2,4]triazolo[1,5-a]pyrimidine system.

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Fizer M., Slivka M. Synthesis of [1,2,4]triazolo[1,5-a]pyrimidine (microreview) // Chemistry of Heterocyclic Compounds. 2016. Vol. 52. No. 3. pp. 155-157.

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Fizer M., Slivka M. Synthesis of [1,2,4]triazolo[1,5-a]pyrimidine (microreview) // Chemistry of Heterocyclic Compounds. 2016. Vol. 52. No. 3. pp. 155-157.

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TY - JOUR

DO - 10.1007/s10593-016-1851-5

UR - https://doi.org/10.1007/s10593-016-1851-5

TI - Synthesis of [1,2,4]triazolo[1,5-a]pyrimidine (microreview)

T2 - Chemistry of Heterocyclic Compounds

AU - Fizer, Maksym

AU - Slivka, Mikhailo

PY - 2016

DA - 2016/03/01

PB - Springer Nature

SP - 155-157

IS - 3

VL - 52

SN - 0009-3122

SN - 1573-8353

ER -

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@article{2016_Fizer,

author = {Maksym Fizer and Mikhailo Slivka},

title = {Synthesis of [1,2,4]triazolo[1,5-a]pyrimidine (microreview)},

journal = {Chemistry of Heterocyclic Compounds},

year = {2016},

volume = {52},

publisher = {Springer Nature},

month = {mar},

url = {https://doi.org/10.1007/s10593-016-1851-5},

number = {3},

pages = {155--157},

doi = {10.1007/s10593-016-1851-5}

}

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Fizer, Maksym, and Mikhailo Slivka. “Synthesis of [1,2,4]triazolo[1,5-a]pyrimidine (microreview).” Chemistry of Heterocyclic Compounds, vol. 52, no. 3, Mar. 2016, pp. 155-157. https://doi.org/10.1007/s10593-016-1851-5.

Издатель

Springer Nature

Журнал

Chemistry of Heterocyclic Compounds

scimago Q4

wos Q4

БС3

SJR

0.243

CiteScore

2.7

Impact factor

ISSN

00093122 (Print)

15738353 (Electronic)