Chemistry of Heterocyclic Compounds

, том 56 , издание 6 , страницы 644-658

Indolo[2,3-a]carbazoles: diversity, biological properties, application in antitumor therapy

Roman G Zenkov ¹

Lidiya V Ektova ¹

Olga А Vlasova ¹

Gennady А Belitskiy ¹

Marianna G Yakubovskaya ¹

Kirill I Kirsanov ^{1, 2}

Скрыть аффилиации авторов Показать аффилиации авторов: 2 аффилиации

N. N. Blokhin Russian Cancer Research Center, Moscow, Russia |

Rudn University, Moscow, Russia |

Тип публикации: Journal Article

Дата публикации: 2020-06-01

Springer Nature

Chemistry of Heterocyclic Compounds

scimago Q4

wos Q4

БС3

SJR: 0.243

CiteScore: 2.7

Impact factor: 1.0

ISSN: 00093122, 15738353

DOI: 10.1007/s10593-020-02714-4

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Organic Chemistry

Краткое описание

This review presents the history of the discovery of indolo[2,3-a]carbazoles, lists the currently known natural compounds of this subclass, and gives the sources for their isolation. The main approaches used to obtain synthetic indolo[2,3-a]carbazoles are described, and examples of compounds from this group that are most promising because of their high antitumor activity are given. The spectrum of biological properties of natural and synthetic compounds of this subclass is highlighted. The molecular mechanisms of their antitumor action as the most significant in the context of clinical use are separately considered. Particular attention is paid to indolo[2,3-a]- carbazoles that have reached clinical trials or are already in use for the treatment of malignant neoplasms.

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Рязанский государственный медицинский университет имени академика И. П. Павлова

Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина Минздрава России

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Максимова Варвара

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Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина Минздрава России

Области научных интересов

Ксенобиотики

Механизмы эпигенетической регуляции транскрипции

Химический канцерогенез

Эпигенетическая противоопухолевая терапия

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Zenkov R. G. et al. Indolo[2,3-a]carbazoles: diversity, biological properties, application in antitumor therapy // Chemistry of Heterocyclic Compounds. 2020. Vol. 56. No. 6. pp. 644-658.

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Zenkov R. G., Ektova L. V., Vlasova O. А., Belitskiy G. А., Yakubovskaya M. G., Kirsanov K. I. Indolo[2,3-a]carbazoles: diversity, biological properties, application in antitumor therapy // Chemistry of Heterocyclic Compounds. 2020. Vol. 56. No. 6. pp. 644-658.

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TY - JOUR

DO - 10.1007/s10593-020-02714-4

UR - https://doi.org/10.1007/s10593-020-02714-4

TI - Indolo[2,3-a]carbazoles: diversity, biological properties, application in antitumor therapy

T2 - Chemistry of Heterocyclic Compounds

AU - Zenkov, Roman G

AU - Ektova, Lidiya V

AU - Vlasova, Olga А

AU - Belitskiy, Gennady А

AU - Yakubovskaya, Marianna G

AU - Kirsanov, Kirill I

PY - 2020

DA - 2020/06/01

PB - Springer Nature

SP - 644-658

IS - 6

VL - 56

SN - 0009-3122

SN - 1573-8353

ER -

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@article{2020_Zenkov,

author = {Roman G Zenkov and Lidiya V Ektova and Olga А Vlasova and Gennady А Belitskiy and Marianna G Yakubovskaya and Kirill I Kirsanov},

title = {Indolo[2,3-a]carbazoles: diversity, biological properties, application in antitumor therapy},

journal = {Chemistry of Heterocyclic Compounds},

year = {2020},

volume = {56},

publisher = {Springer Nature},

month = {jun},

url = {https://doi.org/10.1007/s10593-020-02714-4},

number = {6},

pages = {644--658},

doi = {10.1007/s10593-020-02714-4}

}

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Zenkov, Roman G., et al. “Indolo[2,3-a]carbazoles: diversity, biological properties, application in antitumor therapy.” Chemistry of Heterocyclic Compounds, vol. 56, no. 6, Jun. 2020, pp. 644-658. https://doi.org/10.1007/s10593-020-02714-4.