Indolo[2,3-a]carbazoles: diversity, biological properties, application in antitumor therapy
Publication type: Journal Article
Publication date: 2020-06-01
scimago Q4
wos Q4
SJR: 0.243
CiteScore: 2.7
Impact factor: 1.0
ISSN: 00093122, 15738353
Organic Chemistry
Abstract
This review presents the history of the discovery of indolo[2,3-a]carbazoles, lists the currently known natural compounds of this subclass, and gives the sources for their isolation. The main approaches used to obtain synthetic indolo[2,3-a]carbazoles are described, and examples of compounds from this group that are most promising because of their high antitumor activity are given. The spectrum of biological properties of natural and synthetic compounds of this subclass is highlighted. The molecular mechanisms of their antitumor action as the most significant in the context of clinical use are separately considered. Particular attention is paid to indolo[2,3-a]- carbazoles that have reached clinical trials or are already in use for the treatment of malignant neoplasms.
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Citations from 2024:
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GOST
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Zenkov R. G. et al. Indolo[2,3-a]carbazoles: diversity, biological properties, application in antitumor therapy // Chemistry of Heterocyclic Compounds. 2020. Vol. 56. No. 6. pp. 644-658.
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Zenkov R. G., Ektova L. V., Vlasova O. А., Belitskiy G. А., Yakubovskaya M. G., Kirsanov K. I. Indolo[2,3-a]carbazoles: diversity, biological properties, application in antitumor therapy // Chemistry of Heterocyclic Compounds. 2020. Vol. 56. No. 6. pp. 644-658.
Cite this
RIS
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TY - JOUR
DO - 10.1007/s10593-020-02714-4
UR - https://doi.org/10.1007/s10593-020-02714-4
TI - Indolo[2,3-a]carbazoles: diversity, biological properties, application in antitumor therapy
T2 - Chemistry of Heterocyclic Compounds
AU - Zenkov, Roman G
AU - Ektova, Lidiya V
AU - Vlasova, Olga А
AU - Belitskiy, Gennady А
AU - Yakubovskaya, Marianna G
AU - Kirsanov, Kirill I
PY - 2020
DA - 2020/06/01
PB - Springer Nature
SP - 644-658
IS - 6
VL - 56
SN - 0009-3122
SN - 1573-8353
ER -
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@article{2020_Zenkov,
author = {Roman G Zenkov and Lidiya V Ektova and Olga А Vlasova and Gennady А Belitskiy and Marianna G Yakubovskaya and Kirill I Kirsanov},
title = {Indolo[2,3-a]carbazoles: diversity, biological properties, application in antitumor therapy},
journal = {Chemistry of Heterocyclic Compounds},
year = {2020},
volume = {56},
publisher = {Springer Nature},
month = {jun},
url = {https://doi.org/10.1007/s10593-020-02714-4},
number = {6},
pages = {644--658},
doi = {10.1007/s10593-020-02714-4}
}
Cite this
MLA
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Zenkov, Roman G., et al. “Indolo[2,3-a]carbazoles: diversity, biological properties, application in antitumor therapy.” Chemistry of Heterocyclic Compounds, vol. 56, no. 6, Jun. 2020, pp. 644-658. https://doi.org/10.1007/s10593-020-02714-4.
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