Synthesis of 1,3-Oxazine Derivatives Based on (–)-Isopulegol using the Ritter Reaction and Study of their Analgesic Activity
Тип публикации: Journal Article
Дата публикации: 2020-07-01
scimago Q4
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БС3
SJR: 0.243
CiteScore: 2.7
Impact factor: 1.0
ISSN: 00093122, 15738353
Organic Chemistry
Краткое описание
The Ritter reaction between monoterpenoid (–)-isopulegol and nitriles in the presence of concentrated sulfuric acid or trifluoromethanesulfonic acid yielded a series of chiral 1,3-oxazine derivatives. When studying the analgesic activity of the synthesized compounds in vivo, it was found that 1,3-oxazine synthesized by the reaction of (–)-isopulegol with benzyl cyanide increases the time of latency of the animal in the hot plate test of thermal pain irritation, not inferior in effectiveness to the comparison drug diclofenac sodium.
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Li Zhulanov N. S. et al. Synthesis of 1,3-Oxazine Derivatives Based on (–)-Isopulegol using the Ritter Reaction and Study of their Analgesic Activity // Chemistry of Heterocyclic Compounds. 2020. Vol. 56. No. 7. pp. 936-941.
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Li Zhulanov N. S., Pavlova A. V., Korchagina D. V., Gatilov Y. V., Volcho K. P., Tolstikova T. G., Salakhutdinov N. F. Synthesis of 1,3-Oxazine Derivatives Based on (–)-Isopulegol using the Ritter Reaction and Study of their Analgesic Activity // Chemistry of Heterocyclic Compounds. 2020. Vol. 56. No. 7. pp. 936-941.
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TY - JOUR
DO - 10.1007/s10593-020-02753-x
UR - https://doi.org/10.1007/s10593-020-02753-x
TI - Synthesis of 1,3-Oxazine Derivatives Based on (–)-Isopulegol using the Ritter Reaction and Study of their Analgesic Activity
T2 - Chemistry of Heterocyclic Compounds
AU - Li Zhulanov, Nikolai S
AU - Pavlova, Alla V
AU - Korchagina, Dina V.
AU - Gatilov, Yurii V
AU - Volcho, Konstantin P.
AU - Tolstikova, Tatyana G.
AU - Salakhutdinov, Nariman F.
PY - 2020
DA - 2020/07/01
PB - Springer Nature
SP - 936-941
IS - 7
VL - 56
SN - 0009-3122
SN - 1573-8353
ER -
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@article{2020_Li Zhulanov,
author = {Nikolai S Li Zhulanov and Alla V Pavlova and Dina V. Korchagina and Yurii V Gatilov and Konstantin P. Volcho and Tatyana G. Tolstikova and Nariman F. Salakhutdinov},
title = {Synthesis of 1,3-Oxazine Derivatives Based on (–)-Isopulegol using the Ritter Reaction and Study of their Analgesic Activity},
journal = {Chemistry of Heterocyclic Compounds},
year = {2020},
volume = {56},
publisher = {Springer Nature},
month = {jul},
url = {https://doi.org/10.1007/s10593-020-02753-x},
number = {7},
pages = {936--941},
doi = {10.1007/s10593-020-02753-x}
}
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MLA
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Li Zhulanov, Nikolai S., et al. “Synthesis of 1,3-Oxazine Derivatives Based on (–)-Isopulegol using the Ritter Reaction and Study of their Analgesic Activity.” Chemistry of Heterocyclic Compounds, vol. 56, no. 7, Jul. 2020, pp. 936-941. https://doi.org/10.1007/s10593-020-02753-x.