Synthesis and Analgesic Activity of 4,7-Dimethyl-3,4,4a,5,8,8a-Hexahydro-2H-Chromen-4,8-Diols Containing Thiophene Substituents
A. V. Pavlova
1
,
E V Nazimova
1
,
O S Mikhalchenko
1
,
I. V. Ilina
1, 2
,
D.V. Korchagina
1
,
O V Ardashov
1, 2
,
E. A. Morozova
1
,
T G Tolstikova
1
,
K P Volcho
1, 2
,
N. F. Salakhutdinov
1, 2
Publication type: Journal Article
Publication date: 2016-08-15
scimago Q3
wos Q4
SJR: 0.296
CiteScore: 1.3
Impact factor: 0.9
ISSN: 00093130, 15738388
General Chemistry
General Biochemistry, Genetics and Molecular Biology
Plant Science
Abstract
Hexahydro-2H-chromenes with thiophene fragments were synthesized via reactions of a p-menthane monoterpenoid diol with several thiophenecarboxaldehydes. Most of the synthesized compounds with an additional thiophene fragment displayed analgesic activity in vivo tests at a dose of 10 mg/kg. It was found that the activity in either an acetate-writhing test or a hot-plate test depended on the type and location of substituent in the heteroaromatic ring.
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Pavlova A. V. et al. Synthesis and Analgesic Activity of 4,7-Dimethyl-3,4,4a,5,8,8a-Hexahydro-2H-Chromen-4,8-Diols Containing Thiophene Substituents // Chemistry of Natural Compounds. 2016. Vol. 52. No. 5. pp. 813-820.
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Pavlova A. V., Nazimova E. V., Mikhalchenko O. S., Ilina I. V., Korchagina D., Ardashov O. V., Morozova E. A., Tolstikova T. G., Volcho K. P., Salakhutdinov N. F. Synthesis and Analgesic Activity of 4,7-Dimethyl-3,4,4a,5,8,8a-Hexahydro-2H-Chromen-4,8-Diols Containing Thiophene Substituents // Chemistry of Natural Compounds. 2016. Vol. 52. No. 5. pp. 813-820.
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TY - JOUR
DO - 10.1007/s10600-016-1785-2
UR - https://doi.org/10.1007/s10600-016-1785-2
TI - Synthesis and Analgesic Activity of 4,7-Dimethyl-3,4,4a,5,8,8a-Hexahydro-2H-Chromen-4,8-Diols Containing Thiophene Substituents
T2 - Chemistry of Natural Compounds
AU - Pavlova, A. V.
AU - Nazimova, E V
AU - Mikhalchenko, O S
AU - Ilina, I. V.
AU - Korchagina, D.V.
AU - Ardashov, O V
AU - Morozova, E. A.
AU - Tolstikova, T G
AU - Volcho, K P
AU - Salakhutdinov, N. F.
PY - 2016
DA - 2016/08/15
PB - Springer Nature
SP - 813-820
IS - 5
VL - 52
SN - 0009-3130
SN - 1573-8388
ER -
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BibTex (up to 50 authors)
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@article{2016_Pavlova,
author = {A. V. Pavlova and E V Nazimova and O S Mikhalchenko and I. V. Ilina and D.V. Korchagina and O V Ardashov and E. A. Morozova and T G Tolstikova and K P Volcho and N. F. Salakhutdinov},
title = {Synthesis and Analgesic Activity of 4,7-Dimethyl-3,4,4a,5,8,8a-Hexahydro-2H-Chromen-4,8-Diols Containing Thiophene Substituents},
journal = {Chemistry of Natural Compounds},
year = {2016},
volume = {52},
publisher = {Springer Nature},
month = {aug},
url = {https://doi.org/10.1007/s10600-016-1785-2},
number = {5},
pages = {813--820},
doi = {10.1007/s10600-016-1785-2}
}
Cite this
MLA
Copy
Pavlova, A. V., et al. “Synthesis and Analgesic Activity of 4,7-Dimethyl-3,4,4a,5,8,8a-Hexahydro-2H-Chromen-4,8-Diols Containing Thiophene Substituents.” Chemistry of Natural Compounds, vol. 52, no. 5, Aug. 2016, pp. 813-820. https://doi.org/10.1007/s10600-016-1785-2.