Synthesis and Analgesic Activity of 5,7- and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties
K Yu Ponomarev
1
,
E. A. Morozova
1
,
E V Suslov
1
,
D.V. Korchagina
1
,
T G Tolstikova
1, 2
,
K P Volcho
1, 2
,
N. F. Salakhutdinov
1, 2
Publication type: Journal Article
Publication date: 2017-11-22
scimago Q3
wos Q4
SJR: 0.296
CiteScore: 1.3
Impact factor: 0.9
ISSN: 00093130, 15738388
General Chemistry
General Biochemistry, Genetics and Molecular Biology
Plant Science
Abstract
A series of new compounds combining diazaadamantane and monoterpene moieties that were analogs of highly potent analgesic substituted 5,7-dimethyl-1,3-diazaadamantan-6-ones were prepared by reacting 1,5-diethyl- and 1,5-dipropyl-3,7-diazabicyclo[3.3.1]nonan-9-ones with monoterpenoid aldehydes. Another two structural analogs of these compounds were synthesized by reducing the carbonyl. The biological activity of the prepared compounds was studied in hot-plate and acetate-writhing tests.
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Ponomarev K. Yu. et al. Synthesis and Analgesic Activity of 5,7- and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties // Chemistry of Natural Compounds. 2017. Vol. 53. No. 6. pp. 1131-1136.
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Ponomarev K. Yu., Morozova E. A., Suslov E. V., Korchagina D., Tolstikova T. G., Volcho K. P., Salakhutdinov N. F. Synthesis and Analgesic Activity of 5,7- and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties // Chemistry of Natural Compounds. 2017. Vol. 53. No. 6. pp. 1131-1136.
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TY - JOUR
DO - 10.1007/s10600-017-2216-8
UR - https://doi.org/10.1007/s10600-017-2216-8
TI - Synthesis and Analgesic Activity of 5,7- and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties
T2 - Chemistry of Natural Compounds
AU - Ponomarev, K Yu
AU - Morozova, E. A.
AU - Suslov, E V
AU - Korchagina, D.V.
AU - Tolstikova, T G
AU - Volcho, K P
AU - Salakhutdinov, N. F.
PY - 2017
DA - 2017/11/22
PB - Springer Nature
SP - 1131-1136
IS - 6
VL - 53
SN - 0009-3130
SN - 1573-8388
ER -
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@article{2017_Ponomarev,
author = {K Yu Ponomarev and E. A. Morozova and E V Suslov and D.V. Korchagina and T G Tolstikova and K P Volcho and N. F. Salakhutdinov},
title = {Synthesis and Analgesic Activity of 5,7- and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties},
journal = {Chemistry of Natural Compounds},
year = {2017},
volume = {53},
publisher = {Springer Nature},
month = {nov},
url = {https://doi.org/10.1007/s10600-017-2216-8},
number = {6},
pages = {1131--1136},
doi = {10.1007/s10600-017-2216-8}
}
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MLA
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Ponomarev, K. Yu., et al. “Synthesis and Analgesic Activity of 5,7- and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties.” Chemistry of Natural Compounds, vol. 53, no. 6, Nov. 2017, pp. 1131-1136. https://doi.org/10.1007/s10600-017-2216-8.