Protective Effect of Gentianine, a compound from Du Huo Ji Sheng Tang, against Freund’s Complete Adjuvant-Induced Arthritis in Rats
Publication type: Journal Article
Publication date: 2017-05-13
scimago Q2
wos Q1
SJR: 1.270
CiteScore: 10.1
Impact factor: 5.0
ISSN: 03603997, 15732576
PubMed ID:
28501981
Immunology
Immunology and Allergy
Abstract
The anti-inflammatory property of gentianine (GE) aroused our interest. To investigate the effect of GE on Freund’s complete adjuvant (FCA)-induced arthritis in rats was the aim of this study. Adjuvant-induced arthritis (AA) was induced by the administration of 0.1 ml FCA in the surface of hind paw. Diclofenac sodium (DS) and Fasudil were administered as positive controls. Downregulation of cytokines including interleukin-6 (IL-6), interleukin-1 beta (IL-1β), and tumor necrosis factor-alpha (TNF-α) revealed anti-inflammatory effect of GE, which was consisted with pathological conditions of rat paws. In addition, western blot analysis revealed that GE could strikingly suppressed the expressions of Rho/NF-κB signaling pathways as well as TGF-β/smad-3 pathways. In conclusion, data indicated that GE might contribute to treat arthritis as a potential therapeutic candidate.
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Total citations:
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Citations from 2025:
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(20.69%)
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GOST
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Wenjin Chen, Wang J. Protective Effect of Gentianine, a compound from Du Huo Ji Sheng Tang, against Freund’s Complete Adjuvant-Induced Arthritis in Rats // Inflammation. 2017. Vol. 40. No. 4. pp. 1401-1408.
GOST all authors (up to 50)
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Wenjin Chen, Wang J. Protective Effect of Gentianine, a compound from Du Huo Ji Sheng Tang, against Freund’s Complete Adjuvant-Induced Arthritis in Rats // Inflammation. 2017. Vol. 40. No. 4. pp. 1401-1408.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1007/s10753-017-0583-8
UR - https://doi.org/10.1007/s10753-017-0583-8
TI - Protective Effect of Gentianine, a compound from Du Huo Ji Sheng Tang, against Freund’s Complete Adjuvant-Induced Arthritis in Rats
T2 - Inflammation
AU - Wenjin Chen
AU - Wang, Jianwei
PY - 2017
DA - 2017/05/13
PB - Springer Nature
SP - 1401-1408
IS - 4
VL - 40
PMID - 28501981
SN - 0360-3997
SN - 1573-2576
ER -
Cite this
BibTex (up to 50 authors)
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@article{2017_Wenjin Chen,
author = {Wenjin Chen and Jianwei Wang},
title = {Protective Effect of Gentianine, a compound from Du Huo Ji Sheng Tang, against Freund’s Complete Adjuvant-Induced Arthritis in Rats},
journal = {Inflammation},
year = {2017},
volume = {40},
publisher = {Springer Nature},
month = {may},
url = {https://doi.org/10.1007/s10753-017-0583-8},
number = {4},
pages = {1401--1408},
doi = {10.1007/s10753-017-0583-8}
}
Cite this
MLA
Copy
Wenjin Chen, and Jianwei Wang. “Protective Effect of Gentianine, a compound from Du Huo Ji Sheng Tang, against Freund’s Complete Adjuvant-Induced Arthritis in Rats.” Inflammation, vol. 40, no. 4, May. 2017, pp. 1401-1408. https://doi.org/10.1007/s10753-017-0583-8.