69mZn-containing radiopharmaceuticals: a novel approach to molecular design
MARINA A. ORLOVA
1, 2
,
Tatiana P Trofimova
1, 2
,
Ramiz A Aliev
1, 3
,
Alexey P Orlov
1
,
Sergey V. Nikulin
2
,
Alexey N. Proshin
4
,
Stepan N. Kalmykov
1, 3
4
Department of Organic Synthesis, Institute of Physiological Active Compounds RAS, Chernogolovka, Russia
|
Publication type: Journal Article
Publication date: 2016-10-25
scimago Q2
wos Q3
SJR: 0.388
CiteScore: 2.9
Impact factor: 1.6
ISSN: 02365731, 15882780
Spectroscopy
Analytical Chemistry
Health, Toxicology and Mutagenesis
Public Health, Environmental and Occupational Health
Pollution
Radiology Nuclear Medicine and imaging
Nuclear Energy and Engineering
Abstract
Abstract69mZn was produced and separated for medical applications. Possibilities and perspectives for production of radiopharmaceuticals based on 69mZn containing derivatives of thiazine, thiazoline and thiourea are considered. Each one of the latters is a zinc chelator and a nitric oxide synthase (NOS) effector at the same time. Cytotoxic effect of NOS activator and NOS inhibitors are shown in experiments with HL-60, K-562 and MOLT-4 cell lines and in bone marrow cells of the acute B-lymphoblastic leukemia patients. Some of those compounds are worthy to get selected for further application as radiopharmaceuticals including their antitumor speciements.
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Citations from 2024:
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ORLOVA M. A. et al. 69mZn-containing radiopharmaceuticals: a novel approach to molecular design // Journal of Radioanalytical and Nuclear Chemistry. 2016. Vol. 311. No. 2. pp. 1177-1183.
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ORLOVA M. A., Trofimova T. P., Aliev R. A., Orlov A. P., Nikulin S. V., Proshin A. N., Kalmykov S. N. 69mZn-containing radiopharmaceuticals: a novel approach to molecular design // Journal of Radioanalytical and Nuclear Chemistry. 2016. Vol. 311. No. 2. pp. 1177-1183.
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RIS
Copy
TY - JOUR
DO - 10.1007/s10967-016-5076-y
UR - https://doi.org/10.1007/s10967-016-5076-y
TI - 69mZn-containing radiopharmaceuticals: a novel approach to molecular design
T2 - Journal of Radioanalytical and Nuclear Chemistry
AU - ORLOVA, MARINA A.
AU - Trofimova, Tatiana P
AU - Aliev, Ramiz A
AU - Orlov, Alexey P
AU - Nikulin, Sergey V.
AU - Proshin, Alexey N.
AU - Kalmykov, Stepan N.
PY - 2016
DA - 2016/10/25
PB - Springer Nature
SP - 1177-1183
IS - 2
VL - 311
SN - 0236-5731
SN - 1588-2780
ER -
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BibTex (up to 50 authors)
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@article{2016_ORLOVA,
author = {MARINA A. ORLOVA and Tatiana P Trofimova and Ramiz A Aliev and Alexey P Orlov and Sergey V. Nikulin and Alexey N. Proshin and Stepan N. Kalmykov},
title = {69mZn-containing radiopharmaceuticals: a novel approach to molecular design},
journal = {Journal of Radioanalytical and Nuclear Chemistry},
year = {2016},
volume = {311},
publisher = {Springer Nature},
month = {oct},
url = {https://doi.org/10.1007/s10967-016-5076-y},
number = {2},
pages = {1177--1183},
doi = {10.1007/s10967-016-5076-y}
}
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MLA
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ORLOVA, MARINA A., et al. “69mZn-containing radiopharmaceuticals: a novel approach to molecular design.” Journal of Radioanalytical and Nuclear Chemistry, vol. 311, no. 2, Oct. 2016, pp. 1177-1183. https://doi.org/10.1007/s10967-016-5076-y.
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