Molecular Biology, volume 39, issue 5, pages 646-660
GTPases of the translation apparatus
Publication type: Journal Article
Publication date: 2005-09-01
Journal:
Molecular Biology
Quartile SCImago
Q4
Quartile WOS
Q4
Impact factor: 1.2
ISSN: 00268933, 16083245
Structural Biology
Biophysics
Abstract
Protein biosynthesis is a complex biochemical process involving a number of stages at which different translation factors specifically interact with ribosome. Some of these factors belong to GTP-binding proteins, or G-proteins. Due to their functioning, GTP is hydrolyzed to yield GDP and the inorganic phosphate ion Pi. Interaction with ribosome enhances GTPase activity of translation factors; i.e., ribosome plays a role of GTPase-activating protein (GAP). GTPases involved in translation interact with ribosome at every stage of protein biosynthesis. Initiation factor 2 (IF2) catalyzes initiator tRNA binding to the ribosome P site and subsequent binding of the 50S subunit to the initiation complex of the 30S subunit. Elongation factor Tu (EF-Tu) controls aminoacyl-tRNA delivery to the ribosome A site, while elongation factor G (EF-G) catalyzes translocation of the mRNA-tRNA complex by one codon on the ribosome. Release factor 3 (RF3) catalyzes the release of termination factors 1 or 2 (RF1 or RF2) from the ribosomal complex after completion of protein synthesis and peptidyl-tRNA hydrolysis. The functional properties of translational GTPases as related to other G-proteins, the putative mechanism of GTP hydrolysis, structural features, and the functional cycles of translational GTPases are considered.
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- We do not take into account publications that without a DOI.
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Kubarenko A. V. et al. GTPases of the translation apparatus // Molecular Biology. 2005. Vol. 39. No. 5. pp. 646-660.
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Kubarenko A. V., Sergiev P. V., Rodnina M. GTPases of the translation apparatus // Molecular Biology. 2005. Vol. 39. No. 5. pp. 646-660.
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TY - JOUR
DO - 10.1007/s11008-005-0080-2
UR - https://doi.org/10.1007%2Fs11008-005-0080-2
TI - GTPases of the translation apparatus
T2 - Molecular Biology
AU - Kubarenko, A V
AU - Sergiev, P V
AU - Rodnina, M.V.
PY - 2005
DA - 2005/09/01 00:00:00
PB - Pleiades Publishing
SP - 646-660
IS - 5
VL - 39
SN - 0026-8933
SN - 1608-3245
ER -
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@article{2005_Kubarenko,
author = {A V Kubarenko and P V Sergiev and M.V. Rodnina},
title = {GTPases of the translation apparatus},
journal = {Molecular Biology},
year = {2005},
volume = {39},
publisher = {Pleiades Publishing},
month = {sep},
url = {https://doi.org/10.1007%2Fs11008-005-0080-2},
number = {5},
pages = {646--660},
doi = {10.1007/s11008-005-0080-2}
}
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Kubarenko, A. V., et al. “GTPases of the translation apparatus.” Molecular Biology, vol. 39, no. 5, Sep. 2005, pp. 646-660. https://doi.org/10.1007%2Fs11008-005-0080-2.
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