Synthesis and cytotoxic activity of the products of heterocyclization of trifluoromethylcyanovinyl phosphonates
Тип публикации: Journal Article
Дата публикации: 2009-10-01
scimago Q4
wos Q4
БС3
SJR: 0.219
CiteScore: 1.4
Impact factor: 1
ISSN: 0091150X, 15739031
Drug Discovery
Pharmacology
Краткое описание
Heterocyclization reactions of trifluoromethylcyanovinyl phosphonates (TFMCPs) with aminopyrazoles, aminopyridines, amidines, and arylhydrazines have been studied. It is shown that TFMCPs can be used as precursors of 4,5-dihydropyrazolo[1,5-a]pyrimidines; 4,7-dihydropyrazolo[3,4-b]pyridines; 2H-pyrido-[1,2-a]pyrimidines; 1,4-dihydropyrimidines; 5-oxo-4,5-dihydro-1H-imidazoles; and 2,3-dihydro-1H-pyrazoles modified by both trifluoromethyl and diethoxyphosphoryl groups. The cytotoxic activity of some of the synthesized compounds and a series of fluorinated heterocycles obtained earlier from vinyl phosphonates has been investigated in vitro at the National Cancer Institute (USA) on a standard panel consisting of 60 human tumor-cell lines.
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Shidlovskii A. F. et al. Synthesis and cytotoxic activity of the products of heterocyclization of trifluoromethylcyanovinyl phosphonates // Pharmaceutical Chemistry Journal. 2009. Vol. 43. No. 10. pp. 549-559.
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Shidlovskii A. F., Peregudov A. S., Bulychev Yu. N., Chkanikov N. D. Synthesis and cytotoxic activity of the products of heterocyclization of trifluoromethylcyanovinyl phosphonates // Pharmaceutical Chemistry Journal. 2009. Vol. 43. No. 10. pp. 549-559.
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TY - JOUR
DO - 10.1007/s11094-010-0349-1
UR - https://doi.org/10.1007/s11094-010-0349-1
TI - Synthesis and cytotoxic activity of the products of heterocyclization of trifluoromethylcyanovinyl phosphonates
T2 - Pharmaceutical Chemistry Journal
AU - Shidlovskii, A F
AU - Peregudov, A S
AU - Bulychev, Yu N
AU - Chkanikov, N D
PY - 2009
DA - 2009/10/01
PB - Springer Nature
SP - 549-559
IS - 10
VL - 43
SN - 0091-150X
SN - 1573-9031
ER -
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@article{2009_Shidlovskii,
author = {A F Shidlovskii and A S Peregudov and Yu N Bulychev and N D Chkanikov},
title = {Synthesis and cytotoxic activity of the products of heterocyclization of trifluoromethylcyanovinyl phosphonates},
journal = {Pharmaceutical Chemistry Journal},
year = {2009},
volume = {43},
publisher = {Springer Nature},
month = {oct},
url = {https://doi.org/10.1007/s11094-010-0349-1},
number = {10},
pages = {549--559},
doi = {10.1007/s11094-010-0349-1}
}
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Shidlovskii, A. F., et al. “Synthesis and cytotoxic activity of the products of heterocyclization of trifluoromethylcyanovinyl phosphonates.” Pharmaceutical Chemistry Journal, vol. 43, no. 10, Oct. 2009, pp. 549-559. https://doi.org/10.1007/s11094-010-0349-1.