Synthesis and Biological Activity of Fullerenols with Various Contents of Hydroxyl Groups
Publication type: Journal Article
Publication date: 2013-05-01
scimago Q4
wos Q4
SJR: 0.219
CiteScore: 1.4
Impact factor: 1.0
ISSN: 0091150X, 15739031
Drug Discovery
Pharmacology
Abstract
Polyhydroxyfullerenes, fullerenols with various contents of hydroxy groups, C60(OH)12 – 14, C60(OH)18 – 24, and C60(OH)30 – 38, were synthesized. The first group was insoluble in water and exhibited no biological activity when introduced into cell cultures as suspensions. The other two versions of fullerenols possessed a broad spectrum of antiviral activity in vitro against actual strains of human influenza virus A(H1N1) and A(H3N2), avian influenza A(H5N1), human herpes simplex virus, adenovirus, and respiratory-syncytial virus. The water-soluble versions of fullerenol were non-toxic in vitro toward human and animal cells of various tissue origins. Besides the antiviral activity, the fullerenols demonstrated a protective effect against UVA-induced phototoxicity. The fullerenol version C60(OH)18 – 24 had the maximum biological activity for all studied parameters. The soluble biologically active versions of fullerenol could find application in pharmacology because they could serve as a basis for new effective and non-toxic antiviral and cytoprotective drugs.
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35
Total citations:
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Citations from 2025:
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(2.86%)
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GOST
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Eropkin M. Yu. et al. Synthesis and Biological Activity of Fullerenols with Various Contents of Hydroxyl Groups // Pharmaceutical Chemistry Journal. 2013. Vol. 47. No. 2. pp. 87-91.
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Eropkin M. Yu., Melenevskaya E., Nasonova K. V., Bryazzhikova T. S., Eropkina E. M., Danilenko D. M., Kiselev O. I. Synthesis and Biological Activity of Fullerenols with Various Contents of Hydroxyl Groups // Pharmaceutical Chemistry Journal. 2013. Vol. 47. No. 2. pp. 87-91.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1007/s11094-013-0901-x
UR - https://doi.org/10.1007/s11094-013-0901-x
TI - Synthesis and Biological Activity of Fullerenols with Various Contents of Hydroxyl Groups
T2 - Pharmaceutical Chemistry Journal
AU - Eropkin, M Yu
AU - Melenevskaya, E.Yu
AU - Nasonova, K V
AU - Bryazzhikova, T S
AU - Eropkina, E M
AU - Danilenko, D M
AU - Kiselev, O. I.
PY - 2013
DA - 2013/05/01
PB - Springer Nature
SP - 87-91
IS - 2
VL - 47
SN - 0091-150X
SN - 1573-9031
ER -
Cite this
BibTex (up to 50 authors)
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@article{2013_Eropkin,
author = {M Yu Eropkin and E.Yu Melenevskaya and K V Nasonova and T S Bryazzhikova and E M Eropkina and D M Danilenko and O. I. Kiselev},
title = {Synthesis and Biological Activity of Fullerenols with Various Contents of Hydroxyl Groups},
journal = {Pharmaceutical Chemistry Journal},
year = {2013},
volume = {47},
publisher = {Springer Nature},
month = {may},
url = {https://doi.org/10.1007/s11094-013-0901-x},
number = {2},
pages = {87--91},
doi = {10.1007/s11094-013-0901-x}
}
Cite this
MLA
Copy
Eropkin, M. Yu., et al. “Synthesis and Biological Activity of Fullerenols with Various Contents of Hydroxyl Groups.” Pharmaceutical Chemistry Journal, vol. 47, no. 2, May. 2013, pp. 87-91. https://doi.org/10.1007/s11094-013-0901-x.